Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 1

Odds updated as of 7:11 p.m.

MLB action on Friday includes the San Diego Padres playing the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Padres vs Cardinals Game Info

• San Diego Padres (60-49) vs. St. Louis Cardinals (55-55)
• Date: Friday, August 1, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSMW

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-200) | STL: (+168)
• Spread: SD: -1.5 (+114) | STL: +1.5 (-137)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 10-3, 2.81 ERA vs Matthew Liberatore (Cardinals) - 6-8, 4.04 ERA

The Padres will call on Nick Pivetta (10-3) against the Cardinals and Matthew Liberatore (6-8). When Pivetta starts, his team is 12-9-0 against the spread this season. Pivetta's team has been victorious in 58.3% of the games he's started as the moneyline favorite with a record of 7-5. When Liberatore starts, the Cardinals are 9-10-0 against the spread. The Cardinals are 5-1 in Liberatore's six starts this season that they were the underdog on the moneyline.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.6%)

Padres vs Cardinals Moneyline

• The Padres vs Cardinals moneyline has San Diego as a -200 favorite, while St. Louis is a +168 underdog on the road.

Padres vs Cardinals Spread

• The Padres are favored by 1.5 runs at home versus the Cardinals. The Padres are +114 to cover the spread, while the Cardinals are -137.

Padres vs Cardinals Over/Under

• The Padres-Cardinals contest on Aug. 1 has been given an over/under of 7.5 runs. The over is set at -110 and the under at -110.

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Padres vs Cardinals Betting Trends

• The Padres have won in 32, or 60.4%, of the 53 contests they have been named as odds-on favorites in this year.
• This season San Diego has come away with a win four times in seven chances when named as a favorite of at least -200 on the moneyline.
• The Padres and their opponents have gone over the total this season in 44 of their 107 opportunities.
• The Padres are 59-48-0 against the spread in their 107 games with a line set by sportsbooks this season.
• The Cardinals have won 27 of the 54 games they were listed as the moneyline underdog this season (50%).
• St. Louis has played as a moneyline underdog of +168 or longer in only two games this season, which it lost both.
• In the 107 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 54 times (54-48-5).
• The Cardinals have put together a 56-51-0 record against the spread this season (covering 52.3% of the time).

Padres Player Leaders

• Manny Machado leads San Diego with 127 hits and a team-best slugging percentage of .510. He's batting .302 with an on-base percentage of .362.
• Among qualified hitters in baseball, his batting average ranks seventh, his on-base percentage ranks 26th, and he is 16th in slugging.
• Machado has recorded a base hit in eight games in a row. In his last 10 outings he is batting .429 with four doubles, two home runs and 11 RBIs.
• Fernando Tatis Jr. has 109 hits this season and a team-best OBP of .369. He's batting .269 and slugging .449.
• His batting average is 55th among qualified players, his on-base percentage 20th, and his slugging percentage 64th.
• Tatis has picked up at least one hit in four games in a row. During his last five outings he is batting .278 with two doubles, five walks and an RBI.
• Luis Arraez is batting .295 with a .405 slugging percentage and 41 RBI this year.
• Arraez heads into this game with 13 games in a row with at least one hit. During his last 10 games he is hitting .400 with three doubles, a home run, three walks and five RBIs.
• Xander Bogaerts has been key for San Diego with 103 hits, an OBP of .339 plus a slugging percentage of .383.

Cardinals Player Leaders

• Brendan Donovan has an on-base percentage of .358 and a slugging percentage of .416. Both lead the Cardinals. He's batting .285.
• Including all qualified players, he ranks 24th in batting average, while his on-base percentage ranks 33rd and he is 88th in slugging.
• Alec Burleson has 96 hits to pace his team. He has a batting average of .287 while slugging .469 with an on-base percentage of .341.
• Including all qualified hitters, he ranks 22nd in batting average, 57th in on-base percentage and 41st in slugging percentage.
• Willson Contreras has 28 doubles, 14 home runs and 34 walks while hitting .257.
• Masyn Winn has 23 doubles, seven home runs and 27 walks while hitting .270.

Padres vs Cardinals Head to Head

• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)

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