Orioles vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:12 p.m.

Friday's slate in the MLB includes a matchup between the Baltimore Orioles and the Tampa Bay Rays.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Orioles vs Rays Game Info

• Baltimore Orioles (61-67) vs. Tampa Bay Rays (76-51)
• Date: Friday, August 21, 2026
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: Apple TV+

Orioles vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-116) | TB: (+106)
• Spread: BAL: -1.5 (+168) | TB: +1.5 (-205)
• Total: 7.5 -- Over: (-128) | Under: (+104)

Orioles vs Rays Probable Starting Pitchers

Probable Pitchers: Trevor Rogers (Orioles) - 8-8, 4.15 ERA vs Freddy Peralta (Rays) - 5-10, 5.27 ERA

The Orioles will look to Trevor Rogers (8-8) versus the Rays and Freddy Peralta (5-10). Rogers and his team are 11-12-0 ATS this season when he starts. Rogers' team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 7-7. The Rays have gone 12-13-0 against the spread when Peralta starts. The Rays are 3-6 in Peralta's nine starts this season that they were the underdog on the moneyline.

Orioles vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (53.7%)

Orioles vs Rays Moneyline

• Looking at the moneyline for Orioles-Rays, Baltimore is the favorite at -116, and Tampa Bay is +106 playing on the road.

Orioles vs Rays Spread

• The Rays are +1.5 on the run line against the Orioles. The Rays are -205 to cover, and the Orioles are +168.

Orioles vs Rays Over/Under

• A total of 7.5 runs has been set for the Orioles-Rays contest on Aug. 21, with the over available at -128 and the under at +104.

Bet on Baltimore Orioles vs. Tampa Bay Rays on FanDuel today!

Orioles vs Rays Betting Trends

• The Orioles have been victorious in 29, or 51.8%, of the 56 contests they have been chosen as favorites in this season.
• Baltimore has a record of 28-24 in contests when sportsbooks favor them by -116 or more on the moneyline.
• Contests with the Orioles have gone over the total set by bookmakers in 65 of 127 chances this season.
• In 127 games with a line this season, the Orioles have a mark of 66-61-0 against the spread.
• The Rays have put together a 19-18 record in games they were the underdog on the moneyline (winning 51.4% of those games).
• Tampa Bay has a 10-11 record (winning 47.6% of its games) when playing as a moneyline underdog of +106 or longer.
• The Rays have played in 125 games with a set over/under, and have combined with their opponents to go over the total 59 times (59-64-2).
• The Rays have a 70-55-0 record ATS this season.

Orioles Player Leaders

• Pete Alonso leads Baltimore with 129 hits and an OBP of .360, plus a team-best slugging percentage of .498. He's batting .269.
• Among qualified hitters in baseball, his batting average ranks 45th, his on-base percentage ranks 33rd, and he is 16th in slugging.
• Alonso will look for his 13th straight game with a hit in this contest. In his last 10 games he is hitting .462 with a double, four home runs, four walks and seven RBIs.
• Gunnar Henderson has 23 doubles, four triples, 20 home runs and 53 walks. He's batting .221 and slugging .399 with an on-base percentage of .304.
• Among qualifiers, he is 125th in batting average, 116th in on-base percentage and 99th in slugging percentage.
• Henderson enters this matchup looking to extend his two-game hit streak. During his last five outings he is hitting .222 with two doubles and three walks.
• Leody Taveras has collected 79 base hits, an OBP of .304 and a slugging percentage of .363 this season.
• Samuel Basallo is batting .239 with a .304 OBP and 46 RBI for Baltimore this season.

Rays Player Leaders

• Junior Caminero is leading the Rays with 133 hits. He's batting .274 and slugging .534 with an on-base percentage of .362.
• Including all qualified players in the majors, he is 34th in batting average, 27th in on-base percentage and eighth in slugging percentage.
• Caminero takes a four-game hitting streak into this game. In his last five games he is hitting .250 with a double and two RBIs.
• Yandy Diaz has a .376 OBP while slugging .474. Both are team-highs. He has a batting average of .308.
• He ranks fifth in batting average, 12th in on-base percentage and 31st in slugging percentage in the majors.
• Liam Hicks is batting .284 with 12 doubles, a triple, 16 home runs and 48 walks.
• Jonathan Aranda is hitting .282 with 20 doubles, 15 home runs and 58 walks.

Orioles vs Rays Head to Head

• 8/17/2026: 7-6 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -160, Underdog Moneyline: +148)
• 8/16/2026: 10-2 BAL (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 8/15/2026: 4-3 BAL (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 8/14/2026: 6-5 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 5/27/2026: 11-2 BAL (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/26/2026: 6-1 BAL (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/25/2026: 9-7 BAL (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/20/2026: 5-3 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 5/19/2026: 4-1 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/18/2026: 16-6 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!