Oklahoma vs Missouri Prediction, Odds, Picks, Best Bets for Week 13 2025

The Oklahoma Sooners are among the college football squads busy on Saturday, up against the Missouri Tigers.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Oklahoma vs Missouri Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oklahoma: (-300) | Missouri: (+245)
• Spread: Oklahoma: -7.5 (-106) | Missouri: +7.5 (-114)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Oklahoma vs Missouri Betting Trends

• Oklahoma has beaten the spread six times in 10 games.
• Oklahoma owns one win ATS (1-2) as a 7.5-point favorite or greater this year.
• Two of 10 Oklahoma games have gone over the point total this year.
• Missouri has covered the spread six times in 10 games.
• Of 10 Missouri games so far this year, six have hit the over.

Oklahoma vs Missouri Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Sooners win (76.1%)

Oklahoma vs Missouri Point Spread

Oklahoma is favored by 7.5 points versus Missouri. Oklahoma is -106 to cover the spread, while Missouri is -114.

Oklahoma vs Missouri Over/Under

Oklahoma versus Missouri on Nov. 22 has an over/under of 41.5 points, with the over -110 and the under -110.

Oklahoma vs Missouri Moneyline

Looking at the moneyline for Missouri-Oklahoma, Missouri is the underdog at +245, and Oklahoma is -300.

Oklahoma vs. Missouri Points Insights

Oklahoma vs. Missouri Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: ABC
• Location: Norman, Oklahoma
• Stadium: Gaylord Family Oklahoma Memorial Stadium

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Check out even more in-depth Oklahoma vs. Missouri analysis on FanDuel Research.