Ohio State vs UCLA Prediction, Odds, Picks, Best Bets for Week 12 2025

The Saturday slate in college football includes a matchup between the Ohio State Buckeyes and the UCLA Bruins.

We've got you covered, in terms of the vital information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Ohio State vs UCLA Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-33333) | UCLA: (+4000)
• Spread: Ohio State: -32.5 (-110) | UCLA: +32.5 (-110)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Ohio State vs UCLA Betting Trends

• Against the spread, Ohio State is 7-2-0 this season.
• Ohio State has yet to lose ATS (1-0) as a 32.5-point favorite or greater this year.
• Ohio State has played nine games this year, and three of them have hit the over.
• Against the spread, UCLA is 3-6-0 this season.
• This season, four of UCLA's nine games have gone over the point total.

Ohio State vs UCLA Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (97.4%)

Ohio State vs UCLA Point Spread

UCLA is a 32.5-point underdog against Ohio State. UCLA is -110 to cover the spread, and Ohio State is -110.

Ohio State vs UCLA Over/Under

A total of 48.5 points has been set for the Ohio State-UCLA game on Nov. 15, with the over available at -110 and the under at -110.

Ohio State vs UCLA Moneyline

Ohio State is a -33333 favorite on the moneyline, while UCLA is a +4000 underdog.

Ohio State vs. UCLA Points Insights

Ohio State vs. UCLA Game Info

• Game day: Saturday, November 15, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Columbus, Ohio
• Stadium: Ohio Stadium

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Check out even more in-depth Ohio State vs. UCLA analysis on FanDuel Research.