Ohio State vs Iowa Prediction, Odds, Picks, Best Bets for Week 5 2026

The college football slate on Saturday includes the Ohio State Buckeyes facing the Iowa Hawkeyes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

Ohio State vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-709) | Iowa: (+490)
• Spread: Ohio State: -14.5 (-105) | Iowa: +14.5 (-115)
• Total: 45.5 -- Over: (-105) | Under: (-115)

Ohio State vs Iowa Betting Trends

• Ohio State has covered the spread three times in four games.
• Ohio State has two wins ATS (2-1) as a 14.5-point or higher favorite in 2026.
• There have been three Ohio State games (of four) that hit the over this year.
• Against the spread, Iowa is 3-1-0 this season.
• Iowa has had one game (of four) go over the total this season.

Ohio State vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (70%)

Ohio State vs Iowa Point Spread

Ohio State is a 14.5-point favorite against Iowa. Ohio State is -105 to cover the spread, and Iowa is -115.

Ohio State vs Iowa Over/Under

The over/under for Ohio State-Iowa on Oct. 3 is 45.5. The over is -105, and the under is -115.

Ohio State vs Iowa Moneyline

Looking at the moneyline for Ohio State-Iowa, Ohio State is the favorite at -709, and Iowa is +490.

Ohio State vs. Iowa Points Insights

Ohio State vs. Iowa Game Info

• Game day: Saturday, October 3, 2026
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Ohio State vs. Iowa analysis on FanDuel Research.