Ohio State vs Iowa Prediction, Odds, Picks, Best Bets for Week 5 2026

In college football action on Saturday, the Ohio State Buckeyes play the Iowa Hawkeyes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Ohio State vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Ohio State: (-752) | Iowa: (+520)
• Spread: Ohio State: -14.5 (-110) | Iowa: +14.5 (-110)
• Total: 45.5 -- Over: (-110) | Under: (-110)

Ohio State vs Iowa Betting Trends

• Ohio State has three wins in four games against the spread this season.
• Ohio State has two wins ATS (2-1) as a 14.5-point or higher favorite in 2026.
• This year, three of Ohio State's four games have gone over the point total.
• Iowa has three wins in four contests against the spread this season.
• One Iowa game (out of four) has hit the over this year.

Ohio State vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Buckeyes win (69.1%)

Ohio State vs Iowa Point Spread

Iowa is a 14.5-point underdog against Ohio State. Iowa is -110 to cover the spread, and Ohio State is -110.

Ohio State vs Iowa Over/Under

Ohio State versus Iowa, on Oct. 3, has an over/under of 45.5, with the over being -110 and the under -110.

Ohio State vs Iowa Moneyline

The Ohio State vs Iowa moneyline has Ohio State as a -752 favorite, while Iowa is a +520 underdog.

Ohio State vs. Iowa Points Insights

Ohio State vs. Iowa Game Info

• Game day: Saturday, October 3, 2026
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Iowa City, Iowa
• Stadium: Kinnick Stadium

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Check out even more in-depth Ohio State vs. Iowa analysis on FanDuel Research.