Notre Dame vs Syracuse Prediction, Odds, Picks, Best Bets for Week 13 2025

College football's Saturday schedule includes the Notre Dame Fighting Irish taking on the Syracuse Orange.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Notre Dame vs Syracuse Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (N/A) | Syracuse: (N/A)
• Spread: Notre Dame: -36.5 (-110) | Syracuse: +36.5 (-110)
• Total: 50.5 -- Over: (-115) | Under: (-105)

Notre Dame vs Syracuse Betting Trends

• Notre Dame's record against the spread is 5-5-0.
• There have been five Notre Dame games (of 10) that went over the total this year.
• Syracuse has four wins in 10 contests against the spread this year.
• There have been five Syracuse games (out of 10) that hit the over this season.

Notre Dame vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (98.6%)

Notre Dame vs Syracuse Point Spread

Syracuse is an underdog by 36.5 points against Notre Dame. Syracuse is -110 to cover the spread, and Notre Dame is -110.

Notre Dame vs Syracuse Over/Under

A total of 50.5 points has been set for the Notre Dame-Syracuse game on Nov. 22, with the over available at -115 and the under at -105.

Notre Dame vs. Syracuse Points Insights

Notre Dame vs. Syracuse Game Info

• Game day: Saturday, November 22, 2025
• Game time: 3:30 p.m. ET
• TV channel: NBC
• Location: South Bend, Indiana
• Stadium: Notre Dame Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Notre Dame vs. Syracuse analysis on FanDuel Research.