Notre Dame vs Purdue Prediction, Odds, Picks, Best Bets for Week 4 2025

Saturday's slate in college football includes a matchup between the Notre Dame Fighting Irish and the Purdue Boilermakers.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Notre Dame vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-4000) | Purdue: (+1400)
• Spread: Notre Dame: -24.5 (-115) | Purdue: +24.5 (-105)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Notre Dame vs Purdue Betting Trends

• Notre Dame has no wins against the spread this year.
• Two of two Notre Dame games have hit the over this year.
• Purdue has won twice against the spread this season.
• No Purdue game has hit the over this year.

Notre Dame vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (95.8%)

Notre Dame vs Purdue Point Spread

Purdue is the underdog by 24.5 points against Notre Dame. Purdue is -115 to cover the spread, and Notre Dame is -105.

Notre Dame vs Purdue Over/Under

Notre Dame versus Purdue on Sept. 20 has an over/under of 51.5 points, with the over -110 and the under -110.

Notre Dame vs Purdue Moneyline

Notre Dame is the favorite, -4000 on the moneyline, while Purdue is a +1400 underdog.

Notre Dame vs. Purdue Points Insights

Notre Dame vs. Purdue Game Info

• Game day: Saturday, September 20, 2025
• Game time: 3:30 p.m. ET
• TV channel: NBC
• Location: South Bend, Indiana
• Stadium: Notre Dame Stadium

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Check out even more in-depth Notre Dame vs. Purdue analysis on FanDuel Research.