Notre Dame vs North Carolina Prediction, Odds, Picks, Best Bets for Week 5 2026

In college football action on Saturday, the Notre Dame Fighting Irish take on the North Carolina Tar Heels.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Notre Dame vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-2083) | North Carolina: (+1000)
• Spread: Notre Dame: -21.5 (-104) | North Carolina: +21.5 (-118)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Notre Dame vs North Carolina Betting Trends

• Notre Dame is 3-1-0 against the spread this season.
• Against the spread as 21.5-point or better favorites, Notre Dame is 3-1.
• Notre Dame has had two games (out of four) hit the over this year.
• North Carolina has but one win versus the spread this year.
• North Carolina has had one game (of three) go over the total this season.

Notre Dame vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (92.3%)

Notre Dame vs North Carolina Point Spread

Notre Dame is a 21.5-point favorite against North Carolina. Notre Dame is -104 to cover the spread, and North Carolina is -118.

Notre Dame vs North Carolina Over/Under

A total of 47.5 points has been set for the Notre Dame-North Carolina matchup on Oct. 3, with the over available at -110 and the under at -110.

Notre Dame vs North Carolina Moneyline

North Carolina is the underdog, +1000 on the moneyline, while Notre Dame is a -2083 favorite.

Notre Dame vs. North Carolina Points Insights

Notre Dame vs. North Carolina Game Info

• Game day: Saturday, October 3, 2026
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Chapel Hill, North Carolina
• Stadium: Kenan Stadium

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Check out even more in-depth Notre Dame vs. North Carolina analysis on FanDuel Research.