Notre Dame vs North Carolina Prediction, Odds, Picks, Best Bets for Week 5 2026

The Notre Dame Fighting Irish are among the college football squads in action on Saturday, versus the North Carolina Tar Heels.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Notre Dame vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Notre Dame: (-2326) | North Carolina: (+1060)
• Spread: Notre Dame: -21.5 (-105) | North Carolina: +21.5 (-115)
• Total: 46.5 -- Over: (-110) | Under: (-110)

Notre Dame vs North Carolina Betting Trends

• Notre Dame has three wins in four games against the spread this year.
• Notre Dame's ATS record as 21.5-point or bigger favorites is 3-1.
• Two of Notre Dame's four games have hit the over.
• North Carolina has one win against the spread this year.
• One North Carolina game (out of three) has hit the over this season.

Notre Dame vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Irish win (92.2%)

Notre Dame vs North Carolina Point Spread

North Carolina is the underdog by 21.5 points against Notre Dame. North Carolina is -105 to cover the spread, and Notre Dame is -115.

Notre Dame vs North Carolina Over/Under

Notre Dame versus North Carolina on Oct. 3 has an over/under of 46.5 points, with the over -110 and the under -110.

Notre Dame vs North Carolina Moneyline

The moneyline numbers for Notre Dame vs. North Carolina reveal Notre Dame as the favorite (-2326) and North Carolina as the underdog (+1060).

Notre Dame vs. North Carolina Points Insights

Notre Dame vs. North Carolina Game Info

• Game day: Saturday, October 3, 2026
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Chapel Hill, North Carolina
• Stadium: Kenan Stadium

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Check out even more in-depth Notre Dame vs. North Carolina analysis on FanDuel Research.