Northwestern vs Iowa Prediction, Odds, Picks, Best Bets for Week 10 2026

The college football slate on Saturday includes the Northwestern Wildcats taking on the Iowa Hawkeyes.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Northwestern vs Iowa Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Northwestern: (-137) | Iowa: (+114)
• Spread: Northwestern: -2.5 (-115) | Iowa: +2.5 (-105)
• Total: 45.5 -- Over: (-104) | Under: (-118)

Northwestern vs Iowa Betting Trends

• Northwestern has beaten the spread five times in eight games.
• Northwestern's ATS record as 2.5-point or bigger favorites is 3-2.
• There have been five Northwestern games (of eight) that hit the over this year.
• Iowa is 5-3-0 against the spread this year.
• Iowa has won twice ATS (2-1) as a 2.5-point underdog or more this year.
• A pair of Iowa eight games in 2026 have gone over the point total.

Northwestern vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wildcats win (59.2%)

Northwestern vs Iowa Point Spread

Northwestern is favored by 2.5 points against Iowa. Northwestern is -115 to cover the spread, while Iowa is -105.

Northwestern vs Iowa Over/Under

The Northwestern-Iowa matchup on Nov. 7 has been given an over/under of 45.5 points. The over is -104 and the under is -118.

Northwestern vs Iowa Moneyline

Northwestern is a -137 favorite on the moneyline, while Iowa is a +114 underdog.

Northwestern vs. Iowa Points Insights

Northwestern vs. Iowa Game Info

• Game day: Saturday, November 7, 2026
• Game time: 7:30 p.m. ET
• TV channel: FOX
• Location: Evanston, Illinois
• Stadium: Ryan Field

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Northwestern vs. Iowa analysis on FanDuel Research.