NFL Week 1 Lines: Spreads, Moneylines, and Totals for Every Game

The 2023 NFL season gets underway in less than a week, beginning on September 7th with a high-octane clash between the Chiefs and the Lions.

Here are the NFL betting odds for each game this week.

Lions at Chiefs Week 1 Odds

• Spread: Chiefs (-5.5)
• Lions Moneyline: +190
• Chiefs Moneyline: -230
• Total: 52.5

Patrick Mahomes leads the high-flying Chiefs offense into a game with a 52.5-point total, though it was 54.5 points for a while. Kansas City is en route to a third Super Bowl championship in five years. Their 14-3 record was good enough for a seventh-straight AFC West division win a year ago.

The Lions are looking to build upon a 9-8 season that left them just shy of the playoffs in 2023. That was good enough for them to snap a four-year streak of finishing last in the NFC North, however. Jared Goff's 4,438 passing yards were sixth-most in the NFL, and he also racked up 29 touchdowns with just 7 interceptions.

The clear favorite here is the Chiefs (-5.5), yet they could be without superstar tight end Travis Kelce, who hyperextended his knee in practice on Tuesday. The Kelce injury news has lowered the total and tightened the spread.

49ers at Steelers Week 1 Odds

• Spread: 49ers (-2.5)
• 49ers Moneyline: -132
• Steelers Moneyline: +112
• Total: 41.5

The 49ers are road favorites in Week 1 against the Steelers at Acrisure Stadium.

San Francisco is set to continue its future with Brock Purdy under center. Purdy's passing metrics were extremely positive once accounting for opponents faced in 2023.

As for Kenny Pickett on the other side of things, he likely has touchdown regression coming his way and was around the NFL average in passing efficiency once accounting for opponents.

A defense-centric game is to be expected here with just a 40.5-point total.

Tight end George Kittle remains hampered by a groin injury. Kittle was limited in practice on Wednesday and Thursday.

Panthers at Falcons Week 1 Odds

• Spread: Falcons (-3.5)
• Panthers Moneyline: +166
• Falcons Moneyline: -198
• Total: 39.5

We'll get our first NFL glimpses of some future NFL franchise players in this matchup between the Panthers and Falcons.

For the home team (and the favorite), that means running back Bijan Robinson in a matchup with the Carolina Panthers, a team that ranked top-eight in Expected Points Added (EPA) per carry allowed to opposing running backs in 2022.

But that's burying the lede a bit, as number-one overall pick Bryce Young will be under center for the Panthers.

Young has a pretty solid matchup, as the Falcons ranked 31st in both EPA per play allowed to opposing passers and in pressure rate generated in 2022.

Notably, the total here is trending down and is now 39.5.

DJ Chark and Adam Thielen missed practice on Thursday, and Terrace Marshall, was limited, so the Panthers' pass-catchers are far from 100% entering Week 1.

Texans at Ravens Week 1 Odds

• Spread: Ravens (-10)
• Texans Moneyline: +370
• Ravens Moneyline: -480
• Total: 43.5

This matchup between the Texans and Ravens features Week 1's largest spread with Baltimore favored by a full 10.0 points -- even with a low 43.5-point over/under.

Baltimore, a Super Bowl contender, is looking to elevate itself from a wild card berth, which is what it earned a season ago. Of course, the team lost quarterback Lamar Jackson in Week 13 before losing three of its final four regular season games.

Star tight end Mark Andrews is expected to play in Week 1 but was limited in practice on Wednesday and Thursday.

Houston's hope to reverse course begins with an uphill battle, and number-two overall pick, quarterback CJ Stroud, might need to light up the scoreboard in order to keep pace with the Ravens.

Bengals at Browns Week 1 Odds

• Spread: Bengals (-1.5)
• Bengals Moneyline: -126
• Browns Moneyline: +108
• Total: 47.5

In this Week 1, AFC North battle, the Bengals are road favorites (by 2.5 points) despite a calf injury that is still impacting superstar quarterback Joe Burrow, who returned to practice the week before the season's start. He missed six weeks as a result. Burrow's opponent-adjusted EPA metrics were pristine in 2022, and a return to form will be critical for their chances to make the playoffs for a third consecutive season.

Burrow is "trending" toward playing in Week 1, and he practiced in full on Wednesday and Thursday.

Deshaun Watson's 2022 on-field performance left a lot to be desired for the Cleveland offense. He averaged 6.48 yards per attempt, posted an EPA per drop back mark of -0.22, and was sacked on 10.5% of his drop backs. In just one of his six starts did he clear 250 passing yards.

Offensive expectations are high in this one, though, as the total is 47.5 points.

Buccaneers at Vikings Week 1 Odds

• Spread: Vikings (-5.5)
• Buccaneers Moneyline: +198
• Vikings Moneyline: -240
• Total: 45.5

The Vikings' 2022 season -- coach Kevin O'Connell's first with the team -- ended with a 13-4 regular season yet a 31-24 loss in the wild card round to the New York Giants.

The team still has some questions to answer, namely the legitimacy of their 13-win season. Based on their point differential in 2022, the Vikings had an expected record of 8.4-8.6.

If Justin Jefferson can continue to prove himself as one of the best receivers in the NFL (if not the absolute best), then the offense can carry them to a successful season again. Jefferson has the shortest odds to lead the NFL in receiving yards (+400) of any player.

For the Buccaneers, they also have questions to answer: namely how to proceed after the Tom Brady era. Baker Mayfield earned the starting nod, yet despite a heroic drive in his debut with the Rams, Mayfield underwhelmed statistically last season overall and had a yards-per-attempt rate under 6.50 yards.

It's not a surprise the Vikings are touchdown favorites.

Cardinals at Commanders Week 1 Odds

• Spread: Commanders (-7)
• Cardinals Moneyline: +275
• Commanders Moneyline: -340
• Total: 38.5

A sub-40-point total makes a lot of sense in this matchup between the Cardinals and Commanders.

The Cardinals are without Kyler Murray, who is expected to return to play this season at some point. However, that return date is very much up in the air. Poor quarterback play isn't what you want against a stout Commanders defense that ranked fifth in pressure rate and top-10 in both EPA per pass and per rush allowed in 2022.

Josh Dobbs is expected to start.

On the flip side, Sam Howell earned the starting position for the Commanders. Howell has some rushing ability and could inject some volatility into the Washington offense -- both positive and negative volatility, that is.

The Commanders' top receiver, Terry McLaurin, was upgraded from a limited practice on Wednesday to a full practice on Thursday, a great sign for his chances to play in Week 1.

Titans at Saints Week 1 Odds

• Spread: Saints (-3)
• Titans Moneyline: +138
• Saints Moneyline: -164
• Total: 41.5

Both the Titans and Saints finished 2022 with a 7-10 record, yet these teams seem to be on different trajectories.

Those identical records were despite a -15 point differential for New Orleans and a -61 point differential for the Titans.

Tennessee's win total is set at 7.5 this season; New Orleans' is 9.5.

New Orleans' decision to bring in Derek Carr under center is easy to consider a clear quarterback upgrade. With that said, Andy Dalton played largely to the NFL average last season, and that's where Carr was lingering from an efficiency standpoint with the Raiders.

Jaguars at Colts Week 1 Odds

• Spread: Jaguars (-5)
• Jaguars Moneyline: -240
• Colts Moneyline: +198
• Total: 46.5

Young quarterbacks are the A-plot for this matchup.

Trevor Lawrence has established himself as one of the game's most promising young passers and was one of nine quarterbacks to clear 4,000 passing yards last season.

For the Colts, it's Anthony Richardson, the fourth overall pick from the 2023 NFL Draft. The Florida prospect has some of the highest rushing expectations of any quarterback this season, and he is listed at +300 to lead all quarterbacks in rushing. That trails only Justin Fields (+150).

As a home underdog against a team that was third in pressure rate last season, Richardson could be dropping back and scrambling quite often in Week 1.

Rams at Seahawks Week 1 Odds

• Spread: Seahawks (-4.5)
• Rams Moneyline: +172
• Seahawks Moneyline: -205
• Total: 46.5

There are some pretty big questions surrounding this NFC West clash.

Can Geno Smith continue his breakout in 2023? Smith set career-highs in passing yards (4,282) and touchdowns (30) in 2022.

Can Matthew Stafford bounce back and get the Rams into Super Bowl contention again? Stafford was limited to nine games filled with subpar efficiency.

And how will the Rams' offense operate with Cooper Kupp ruled out for Week 1?

This game is setting up as a high-scoring matchup, and we'll probably learn a lot about each offense here. Of note, the total is trending down a bit, likely due to the Kupp news.

Another new note here: Seattle RB Kenneth Walker was limited in practice on Thursday.

Eagles at Patriots Week 1 Odds

• Spread: Eagles (-4)
• Eagles Moneyline: -210
• Patriots Moneyline: +176
• Total: 45

The Eagles are road favorites in their attempt to avoid the dangerous Super Bowl hangover. With a win total of 11.5 and a new, explosive running back in D'Andre Swift, Philadelphia's expectations are rightfully high entering the 2023 season.

For the Patriots, their win total is set at just 7.5 with -142 odds on the under, meaning they may be at least one more year from a return to former glory.

The team might need to get the ball out of quarterback Mac Jones' hands, as the Eagles had some record-setting pass-rush numbers a year ago.

Raiders at Broncos Week 1 Odds

• Spread: Broncos (-3.5)
• Raiders Moneyline: +138
• Broncos Moneyline: -164
• Total: 44

Year Two for the Russell Wilson era in Denver will be some must-watch television. Wilson threw for 3,524 yards and just 16 touchdowns in 2022, though the underlying data says he should've had more touchdowns. One of the most talented passers in the NFL has plenty of room for growth under new coach Sean Payton.

As of Monday, wide receiver Jerry Jeudy was still limited to conditioning work in practice, and he was limited in practice on Wednesday and Thursday.

The Raiders' expectations for 2023 are, well, not super high. Their win total of 6.5 comes with -138 odds on the under. Jimmy Garoppolo will need to find a rapport with Davante Adams quickly to maximize on their offensive potential after running back Josh Jacobs agreed to a one-year deal with the Raiders.

Packers at Bears Week 1 Odds

• Spread: Bears (-1.5)
• Packers Moneyline: -102
• Bears Moneyline: -116
• Total: 41.5

It'll take some getting used to seeing the Packers without Aaron Rodgers, and it'll especially take some getting used to seeing a Rodgers-less Packers team playing the Chicago Bears.

But we're getting that right off the bat in Week 1 with one of the tightest spreads and lowest totals of the opening week.

The total is trending down with news of injuries to Packers WRs Christian Watson and Romeo Doubs. Both were inactive in practice on Wednesday. Watson missed practice again on Thursday, but Doubs was upgraded to limited.

Justin Fields will look to piece together another historic rushing season after going for 1,143 yards on the ground in 2022. He's the favorite to lead all quarterbacks in rushing yards (+150) in 2023.

Dolphins at Chargers Week 1 Odds

• Spread: Chargers (-3)
• Dolphins Moneyline: +130
• Chargers Moneyline: -154
• Total: 50.5

It's not a surprise that the total for this matchup is north of 50 points.

The Dolphins have dynamic pass-catchers in Tyreek Hill and Jaylen Waddle, and Tua Tagovailoa posted some of the best per-attempt numbers in the NFL in 2022. They do have some running back questions, however, as Jeff Wilson Jr. is on IR, but De'Von Achane avoided a serious shoulder injury in the preseason and is back at practice.

And the Chargers can answer the call offensively -- especially with Kellen Moore as their new offensive coordinator.

Los Angeles ranked top-10 in yards per game and second in plays per game last season.

Cowboys at Giants Week 1 Odds

• Spread: Cowboys (-3.5)
• Cowboys Moneyline: -180
• Giants Moneyline: +152
• Total: 45.5

A 12-5 record was good enough for just a wild card berth last season for the Cowboys because the Eagles ran away with the NFC East, but the Giants (9-7-1) were also a wild card squad a year ago. Each lost in the divisional round, as well.

This time around, the Cowboys are favored by 3.5 on the road.

They're re-tooled with wide receiver Brandin Cooks and fourth-round tight end Jake Ferguson joining an already dangerous offense.

The Giants were 20th in Passing EPA per play in 2022 -- but top-three in rushing.

Year Two under Brian Daboll could get off on the right foot with an upset victory.

Bills at Jets Week 1 Odds

• Spread: Bills (-2.5)
• Bills Moneyline: -142
• Jets Moneyline: +118
• Total: 45.5

A high-profile quarterback matchup rounds out Week 1 on Monday Night Football.

The Jets will see Aaron Rodgers' first start come as home underdogs against division rivals, the Bills.

Rodgers' efficiency last season was right below the NFL average, so we'll need to see a bounce-back campaign for the Jets to get close to their win total of 9.5 (with -122 odds on the over).

The Bills' win total is 10.5 (-144 on the over). They've hit 11-plus wins in three consecutive seasons.

While there will be plenty of season left after Monday Night Football, this game might prove very important by late December.

Stud running backs Breece Hall and Dalvin Cook are expected to play in Week 1 for the Jets with no snap count restriction for either player. Fantasy managers will surely keep a close eye on the split.

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