NFL Preseason Predictions & Picks: 3 Best Bets Today for the Final Preseason Games

NFL Betting Picks in Summary

• Colts -3.5
• Titans -2.5
• Lions-Colts Under 36.5

These are the final two games of the entire 2026 preseason — every other team around the league has already finished, and rosters must be cut from 90 to 53 by 6 p.m. ET the very next day. For the players on the bubble in these two games, tonight is genuinely the last chance to make a case.

All NFL preseason odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

NFL Predictions and Picks for the Preseason Finale

Detroit Lions at Indianapolis Colts (Sat, 1 p.m. ET)

Colts -3.5 (-118)

A modest home favorite for the final game of the preseason, with nothing specific to argue against the number.

Chicago Bears at Tennessee Titans (Sat, 6 p.m. ET)

Titans -2.5 (-120)

Cam Ward and Tennessee's confirmed group have looked sharp through multiple weeks of the preseason, and that continuity is worth trusting to close out the year at home.

Lions-Colts Under 36.5 (-120)

The absolute final week of camp before cutdown day means the deepest rosters of the entire preseason are on the field, which tends to produce more stalled drives than clean scoring.