NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 5

The San Francisco 49ers versus the Seattle Seahawks is a game to see on a Week 5 NFL slate that includes plenty of competitive contests.

Here's what you need to know in terms of the betting odds for Week 5 in the NFL.

Cowboys vs. Buccaneers

CeeDee Lamb will lead the Dallas Cowboys (2-2) into their matchup against the Tampa Bay Buccaneers (0-4) at AT&T Stadium on Thursday at 8:15 p.m. ET.

• Game Preview: Tampa Bay Buccaneers at Dallas Cowboys
• Projected Favorite: Cowboys (64.86% win probability)
• Spread: Dallas (-8.5)
• Total: 47.5 -- Over: (-112) | Under: (-108)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Dallas vs. Tampa Bay with FanDuel Sportsbook.

Jaguars vs. Eagles

At 9:30 a.m. ET on Sunday, the Philadelphia Eagles (2-2) take on the Jacksonville Jaguars (3-1).

• Game Preview: Philadelphia Eagles vs. Jacksonville Jaguars
• Projected Favorite: Jaguars (73.30% win probability)
• Spread: Jacksonville (-7)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Jacksonville vs. Philadelphia with FanDuel Sportsbook.

Steelers vs. Colts

The Pittsburgh Steelers (2-2) are slated to collide with the Indianapolis Colts (2-2) at Acrisure Stadium on Sunday, Oct. 11 at 1 p.m. ET. In their previous games, the Steelers were taken down by the Browns 27-24, and the Colts won 30-13 against the Commanders.

• Game Preview: Indianapolis Colts at Pittsburgh Steelers
• Projected Favorite: Colts (56.36% win probability)
• Spread: Pittsburgh (-1.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Indianapolis with FanDuel Sportsbook.

Dolphins vs. Bengals

After losing 22-17 to the Jaguars in their last tilt, the Cincinnati Bengals (2-2) will visit the Miami Dolphins (0-4), who are coming off a 15-10 loss to the Vikings, at Hard Rock Stadium. The game is scheduled for 1 p.m. ET on Sunday, Oct. 11.

• Game Preview: Cincinnati Bengals at Miami Dolphins
• Projected Favorite: Bengals (61.62% win probability)
• Spread: Cincinnati (-7.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Miami vs. Cincinnati with FanDuel Sportsbook.

Jets vs. Browns

The New York Jets (1-3) are slated to collide with the Cleveland Browns (3-1) at MetLife Stadium on Sunday, Oct. 11 at 1 p.m. ET. In their previous contests, the Jets were defeated by the Bears 23-12, and the Browns won 27-24 against the Steelers.

• Game Preview: Cleveland Browns at New York Jets
• Projected Favorite: Jets (56.93% win probability)
• Spread: New York (-1.5)
• Total: 40.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Cleveland with FanDuel Sportsbook.

Titans vs. Texans

The Houston Texans (0-4) and the Tennessee Titans (0-4), who both lost their last tilt, will square off at 1 p.m. ET on Sunday, Oct. 11. In their previous games, the Texans lost 34-30 to the Cowboys, and the Titans were defeated by the Ravens 24-18.

• Game Preview: Houston Texans at Tennessee Titans
• Projected Favorite: Texans (72.07% win probability)
• Spread: Houston (-7)
• Total: 37.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Houston with FanDuel Sportsbook.

Saints vs. Vikings

One of the top pass-catchers in football will be featured when Chris Olave and the New Orleans Saints (1-3) host the Minnesota Vikings (4-0) on Sunday, October 11, 2026.

• Game Preview: Minnesota Vikings at New Orleans Saints
• Projected Favorite: Vikings (51.33% win probability)
• Spread: Minnesota (-1.5)
• Total: 42.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Minnesota with FanDuel Sportsbook.

Commanders vs. Giants

On Sunday, Oct. 11 at 1 p.m. ET, the Washington Commanders (1-3) will attempt to bounce back from their recent 30-13 loss to the Colts when they take on the New York Giants (3-1) at Northwest Stadium. The Giants won their last game 36-24 against the Cardinals.

• Game Preview: New York Giants at Washington Commanders
• Projected Favorite: Commanders (56.50% win probability)
• Spread: Washington (-3.5)
• Total: 43.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. New York with FanDuel Sportsbook.

Patriots vs. Raiders

When the New England Patriots (2-2) and the Las Vegas Raiders (3-1) play on Sunday, Oct. 11 at 1 p.m. ET, the Patriots will be aiming to follow up their recent victory over the Bills with another win, and the Raiders will be trying to rebound from a loss to the Chiefs.

• Game Preview: Las Vegas Raiders at New England Patriots
• Projected Favorite: Patriots (73.51% win probability)
• Spread: New England (-3.5)
• Total: 45.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Las Vegas with FanDuel Sportsbook.

Packers vs. Bears

The Green Bay Packers (2-2) and their 28th-ranked run defense might have a hard time slowing down the Chicago Bears (3-1) and Kyle Monangai, one of the league's top runners, when the Packers host the Bears at Lambeau Field on Oct. 11 at 1 p.m. ET.

• Game Preview: Chicago Bears at Green Bay Packers
• Projected Favorite: Bears (61.29% win probability)
• Spread: Chicago (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Green Bay vs. Chicago with FanDuel Sportsbook.

Chargers vs. Broncos

The Denver Broncos (2-2) are in action on Sunday at 4:05 p.m. ET versus the Los Angeles Chargers (0-4) at SoFi Stadium.

• Game Preview: Denver Broncos at Los Angeles Chargers
• Projected Favorite: Broncos (53.03% win probability)
• Spread: Denver (-3.5)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Denver with FanDuel Sportsbook.

Cardinals vs. Lions

One of the top running backs in football will be on display when Jahmyr Gibbs and the Detroit Lions (2-2) visit the Arizona Cardinals (1-3) on Sunday, October 11, 2026.

• Game Preview: Detroit Lions at Arizona Cardinals
• Projected Favorite: Lions (66.44% win probability)
• Spread: Detroit (-5.5)
• Total: 53.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Arizona vs. Detroit with FanDuel Sportsbook.

Seahawks vs. 49ers

The San Francisco 49ers (4-0), who rank second in the league by scoring 30.5 points per game, will be tested by the fifth-ranked scoring defense of the Seattle Seahawks (3-1), who allow opponents to score 18.3 per game. The matchup begins at 4:25 p.m. ET on Sunday, Oct. 11 at Lumen Field.

• Game Preview: San Francisco 49ers at Seattle Seahawks
• Projected Favorite: Seahawks (57.37% win probability)
• Spread: Seattle (-3)
• Total: 47.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Seattle vs. San Francisco with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!