NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 10

The Week 10 NFL lineup features several top-tier games, including the matchup between the Pittsburgh Steelers and the Cincinnati Bengals.

If you're seeking additional betting information for Week 10 in the NFL, we have you covered with odds for each of the important matchups.

Giants vs. Commanders

The New York Giants (5-2-1) are in action on Thursday at 8:15 p.m. ET against the Washington Commanders (2-5-1) at MetLife Stadium.

• Game Preview: Washington Commanders at New York Giants
• Projected Favorite: Giants (58.17% win probability)
• Spread: New York (-1.5)
• Total: 41.5 -- Over: (+100) | Under: (-120)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on New York vs. Washington with FanDuel Sportsbook.

Lions vs. Patriots

Amon-Ra St. Brown and the Detroit Lions (6-2) will take on Drake Maye and the New England Patriots (5-4) on Sunday at 9:30 a.m. ET, in a matchup featuring two of the biggest offensive stars in football.

• Game Preview: New England Patriots vs. Detroit Lions
• Projected Favorite: Lions (62.20% win probability)
• Spread: Detroit (-2.5)
• Total: 51.5 -- Over: (-105) | Under: (-115)
• Time: 9:30 a.m. ET
• Channel: FOX

Bet on Detroit vs. New England with FanDuel Sportsbook.

Falcons vs. Chiefs

The Kansas City Chiefs (6-2), who took down the Jets in their previous tilt, visit the Atlanta Falcons (3-6) at Mercedes-Benz Stadium on Nov. 15 at 1 p.m. ET. The Falcons were defeated by the Bengals in their last game.

• Game Preview: Kansas City Chiefs at Atlanta Falcons
• Projected Favorite: Chiefs (72.38% win probability)
• Spread: Kansas City (-3.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Kansas City with FanDuel Sportsbook.

Colts vs. Dolphins

The Indianapolis Colts (2-7) will host the Miami Dolphins (1-7) on Sunday at 1 p.m. ET.

• Game Preview: Miami Dolphins at Indianapolis Colts
• Projected Favorite: Colts (50.32% win probability)
• Spread: Indianapolis (-3.5)
• Total: 37.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Miami with FanDuel Sportsbook.

Packers vs. Vikings

Jordan Love and the Green Bay Packers (6-3) will get a tough test when they square off against the Minnesota Vikings (6-2), who own the NFL's second-best pass D, on Sunday, Nov. 15 at 1 p.m. ET. Love ranks first in the league in passing yards.

• Game Preview: Minnesota Vikings at Green Bay Packers
• Projected Favorite: Packers (70.25% win probability)
• Spread: Green Bay (-3.5)
• Total: 42.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Green Bay vs. Minnesota with FanDuel Sportsbook.

Jets vs. Bills

The Buffalo Bills (7-1), who grabbed a win against the Vikings in their last contest, visit the New York Jets (2-7) at MetLife Stadium on Nov. 15 at 1 p.m. ET. The Jets lost to the Chiefs in their last game.

• Game Preview: Buffalo Bills at New York Jets
• Projected Favorite: Bills (69.47% win probability)
• Spread: Buffalo (-7.5)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Buffalo with FanDuel Sportsbook.

Saints vs. Panthers

The New Orleans Saints (3-5) play on Sunday at 1 p.m. ET versus the Carolina Panthers (3-5) at Caesars Superdome.

• Game Preview: Carolina Panthers at New Orleans Saints
• Projected Favorite: Saints (61.53% win probability)
• Spread: New Orleans (-2.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Carolina with FanDuel Sportsbook.

Browns vs. Texans

When the Houston Texans (3-5) and the Cleveland Browns (5-4) match up on Sunday, Nov. 15 at 1 p.m. ET, the Texans will be looking to follow up their recent victory over the Chargers with another win, and the Browns will be trying to rebound from a loss to the Saints.

• Game Preview: Houston Texans at Cleveland Browns
• Projected Favorite: Texans (66.22% win probability)
• Spread: Houston (-4.5)
• Total: 39.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Houston with FanDuel Sportsbook.

Titans vs. Jaguars

When the Tennessee Titans (1-7) and the Jacksonville Jaguars (6-2) compete on Sunday, Nov. 15 at 1 p.m. ET, the Titans' 28th-ranked scoring offense will have its hands full, as the Jaguars sport the second-ranked defense in the league.

• Game Preview: Jacksonville Jaguars at Tennessee Titans
• Projected Favorite: Jaguars (71.10% win probability)
• Spread: Jacksonville (-10.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Jacksonville with FanDuel Sportsbook.

Raiders vs. Seahawks

Brock Bowers and the Las Vegas Raiders (4-5) will get a challenge when they square off against the Seattle Seahawks (5-4), who have the league's best pass D, on Sunday, Nov. 15 at 4:05 p.m. ET. Bowers ranks ninth-best in the NFL in receiving yards.

• Game Preview: Seattle Seahawks at Las Vegas Raiders
• Projected Favorite: Seahawks (70.04% win probability)
• Spread: Seattle (-6.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Seattle with FanDuel Sportsbook.

Cardinals vs. Rams

Trey McBride and the Arizona Cardinals (3-6) meet the Los Angeles Rams (5-4) on Sunday at 4:05 p.m. ET at State Farm Stadium.

• Game Preview: Los Angeles Rams at Arizona Cardinals
• Projected Favorite: Rams (73.61% win probability)
• Spread: Los Angeles (-9.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Los Angeles with FanDuel Sportsbook.

Cowboys vs. 49ers

The 4:25 p.m. ET tilt on Nov. 15 between the Dallas Cowboys (4-5) and the San Francisco 49ers (7-1) should be a fun matchup, as Javonte Williams has been one of the league's top rushers this season, and the 49ers have been a top-five run defense, ranking second-best in the NFL with 80.9 rushing yards surrendered per contest.

• Game Preview: San Francisco 49ers at Dallas Cowboys
• Projected Favorite: 49ers (64.74% win probability)
• Spread: San Francisco (-4.5)
• Total: 55.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Dallas vs. San Francisco with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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