NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 10

The Week 10 NFL Sunday schedule features plenty of excitement, including a matchup between the Pittsburgh Steelers and the Cincinnati Bengals.

If you're seeking additional betting intel for Sunday's Week 10 NFL action, we have you covered with betting odds for all the big games.

Lions vs. Patriots

On Sunday, Nov. 15 at 9:30 a.m. ET, the Detroit Lions (6-2) will try to build upon their recent 19-9 win over the Dolphins when they take on the New England Patriots (5-4) at Allianz Arena. The Patriots lost their previous contest 45-27 to the Packers.

• Game Preview: New England Patriots vs. Detroit Lions
• Projected Favorite: Lions (62.20% win probability)
• Spread: Detroit (-2.5)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: FOX

Bet on Detroit vs. New England with FanDuel Sportsbook.

Browns vs. Texans

After a 44-22 victory versus the Chargers in their previous game, the Houston Texans (3-5) will visit the Cleveland Browns (5-4), who are coming off a 23-22 loss to the Saints. The game is slated for 1 p.m. ET on Sunday, Nov. 15.

• Game Preview: Houston Texans at Cleveland Browns
• Projected Favorite: Texans (66.22% win probability)
• Spread: Houston (-4.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Houston with FanDuel Sportsbook.

Colts vs. Dolphins

On Sunday at 1 p.m. ET, the Indianapolis Colts (2-7) will host the Miami Dolphins (1-7).

• Game Preview: Miami Dolphins at Indianapolis Colts
• Projected Favorite: Colts (50.32% win probability)
• Spread: Indianapolis (-3.5)
• Total: 37.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Miami with FanDuel Sportsbook.

Packers vs. Vikings

Christian Watson and the Green Bay Packers (6-3) will get a tough test when they square off against the Minnesota Vikings (6-2), who have the NFL's second-best pass defense, on Sunday, Nov. 15 at 1 p.m. ET. Watson is third-best in the league in receiving yards.

• Game Preview: Minnesota Vikings at Green Bay Packers
• Projected Favorite: Packers (68.20% win probability)
• Spread: Green Bay (-3)
• Total: 42.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Green Bay vs. Minnesota with FanDuel Sportsbook.

Saints vs. Panthers

Against the New Orleans Saints (3-5), who have the 29th-ranked run defense this season, Chuba Hubbard and the Carolina Panthers (3-5) shouldn't have any trouble running the ball when the two teams square off on Sunday, Nov. 15 at 1 p.m. ET. Hubbard has been one of the NFL's top rushers this year, ranking 10th-best in the league in rushing yards.

• Game Preview: Carolina Panthers at New Orleans Saints
• Projected Favorite: Saints (61.53% win probability)
• Spread: New Orleans (-2.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Carolina with FanDuel Sportsbook.

Titans vs. Jaguars

Nissan Stadium is the venue where the Jacksonville Jaguars (6-2) will take on the Tennessee Titans (1-7) on Sunday, November 15, 2026.

• Game Preview: Jacksonville Jaguars at Tennessee Titans
• Projected Favorite: Jaguars (71.10% win probability)
• Spread: Jacksonville (-10.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Jacksonville with FanDuel Sportsbook.

Jets vs. Bills

The Buffalo Bills (7-1) are slated to match up with the New York Jets (2-7) at MetLife Stadium on Sunday, Nov. 15 at 1 p.m. ET. In their previous games, the Bills defeated the Vikings 23-6, and the Jets lost 35-12 to the Chiefs.

• Game Preview: Buffalo Bills at New York Jets
• Projected Favorite: Bills (69.47% win probability)
• Spread: Buffalo (-7.5)
• Total: 50.5 -- Over: (-120) | Under: (+100)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Buffalo with FanDuel Sportsbook.

Falcons vs. Chiefs

The Kansas City Chiefs (6-2) visit the Atlanta Falcons (3-6) on Sunday at 1 p.m. ET, in a battle between a pair of the top offensive players in football in wideout Travis Kelce and running back Bijan Robinson.

• Game Preview: Kansas City Chiefs at Atlanta Falcons
• Projected Favorite: Chiefs (72.38% win probability)
• Spread: Kansas City (-3.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Kansas City with FanDuel Sportsbook.

Cardinals vs. Rams

The Los Angeles Rams (5-4) visit the Arizona Cardinals (3-6) on Sunday at 4:05 p.m. ET, in a battle between two excellent pass-catchers in Puka Nacua and Trey McBride.

• Game Preview: Los Angeles Rams at Arizona Cardinals
• Projected Favorite: Rams (73.61% win probability)
• Spread: Los Angeles (-9.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Los Angeles with FanDuel Sportsbook.

Raiders vs. Seahawks

Brock Bowers, who ranks ninth-best in the NFL in receiving yards, will aim to lead the charge for the Las Vegas Raiders (4-5) on Nov. 15 at 4:05 p.m. ET, when they host the Seattle Seahawks (5-4) and their first-ranked pass D (155.1 passing yards allowed per game).

• Game Preview: Seattle Seahawks at Las Vegas Raiders
• Projected Favorite: Seahawks (70.04% win probability)
• Spread: Seattle (-6.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Seattle with FanDuel Sportsbook.

Cowboys vs. 49ers

On Sunday at 4:25 p.m. ET, a pair of star running backs will be on display when Christian McCaffrey and the San Francisco 49ers (7-1) visit Javonte Williams and the Dallas Cowboys (4-5).

• Game Preview: San Francisco 49ers at Dallas Cowboys
• Projected Favorite: 49ers (64.74% win probability)
• Spread: San Francisco (-4.5)
• Total: 55.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Dallas vs. San Francisco with FanDuel Sportsbook.

Bengals vs. Steelers

The Cincinnati Bengals (6-2), who rank second in the league by scoring 30.0 points per game, will have a test from the fourth-ranked scoring defense of the Pittsburgh Steelers (6-2), who allow opponents to score 18.0 per game. The matchup starts at 8:20 p.m. ET on Sunday, Nov. 15 at Paycor Stadium.

• Game Preview: Pittsburgh Steelers at Cincinnati Bengals
• Projected Favorite: Bengals (61.03% win probability)
• Spread: Cincinnati (-3.5)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Cincinnati vs. Pittsburgh with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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