Nebraska vs Michigan State Prediction, Odds, Picks, Best Bets for Week 6 2025

5mo

Subscribe to our newsletter

Saturday's slate in college football includes a matchup between the Nebraska Cornhuskers and the Michigan State Spartans.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Nebraska vs Michigan State Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Nebraska: (-450) | Michigan State: (+350)
Spread: Nebraska: -12.5 (-105) | Michigan State: +12.5 (-115)
Total: 48.5 -- Over: (-110) | Under: (-110)

Nebraska has won twice against the spread this season.
Nebraska has yet to lose ATS (2-0) as a 12.5-point favorite or greater this year.
This season, three of Nebraska's four games have gone over the point total.
Michigan State has one win against the spread this season.
Michigan State has covered every time (1-0) as a 12.5-point or greater underdog this season.
There have been three Michigan State games (out of four) that hit the over this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (74.8%)

Michigan State is listed as an underdog by 12.5 points (-115 odds), and Nebraska, the favorite, is -105 to cover.

The over/under for Nebraska-Michigan State on Oct. 4 is 48.5. The over is -110, and the under is -110.

Looking at the moneyline for Michigan State-Nebraska, Michigan State is the underdog at +350, and Nebraska is -450.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Nebraska	43.5	27	13.5	10	51.0	4
Michigan State	34.3	68	28.8	80	51.5	4

Check out even more in-depth Nebraska vs. Michigan State analysis on FanDuel Research.

Want more stories like this?