Friday’s MLB Strikeout Props - Sept. 25

Will Tarik Skubal strike out more than 7.5 batters? Can Clay Holmes surpass 3.5 strikeouts? See their odds and more strikeout prop odds for all pitchers in MLB play on Sept. 25, in the article below.

Today's MLB Strikeout Props

Cincinnati Reds at Toronto Blue Jays

• Nick Lodolo (Reds): Over/Under 4.5 Ks (Over +126, Under -162) | 2026 Stats: 4 strikeouts per game in 20 appearances
• José Soriano (Blue Jays): Over/Under 5.5 Ks (Over -132, Under +104) | 2026 Stats: 5.4 strikeouts per game in 31 appearances

Baltimore Orioles at New York Yankees

• Brendan Beck (Yankees): Over/Under 4.5 Ks (Over -140, Under +110) | 2026 Stats: 3.2 strikeouts per game in 4 appearances
• Trevor Rogers (Orioles): Over/Under 6.5 Ks (Over +104, Under -132) | 2026 Stats: 5.2 strikeouts per game in 30 appearances

Chicago Cubs at Boston Red Sox

• Clay Holmes (Cubs): Over/Under 3.5 Ks (Over -154, Under +120) | 2026 Stats: 4.3 strikeouts per game in 18 appearances

Texas Rangers at Minnesota Twins

• Jacob deGrom (Rangers): Over/Under 6.5 Ks (Over +100, Under -128) | 2026 Stats: 6.5 strikeouts per game in 30 appearances

St. Louis Cardinals at Milwaukee Brewers

• Michael McGreevy (Cardinals): Over/Under 3.5 Ks (Over -122, Under -104) | 2026 Stats: 3.8 strikeouts per game in 30 appearances
• Robert Gasser (Brewers): Over/Under 4.5 Ks (Over -136, Under +106) | 2026 Stats: 4.7 strikeouts per game in 20 appearances

Colorado Rockies at Chicago White Sox

• Sean Burke (White Sox): Over/Under 5.5 Ks (Over -138, Under +108) | 2026 Stats: 5.7 strikeouts per game in 31 appearances
• Tomoyuki Sugano (Rockies): Over/Under 3.5 Ks (Over -118, Under -108) | 2026 Stats: 3.2 strikeouts per game in 28 appearances

Los Angeles Dodgers at San Francisco Giants

• Tarik Skubal (Dodgers): Over/Under 7.5 Ks (Over -104, Under -122) | 2026 Stats: 7 strikeouts per game in 25 appearances

Atlanta Braves at Miami Marlins

• Eury Pérez (Marlins): Over/Under 4.5 Ks (Over -166, Under +130) | 2026 Stats: 5.6 strikeouts per game in 29 appearances

Pittsburgh Pirates at Detroit Tigers

• Jackson Jobe (Tigers): Over/Under 5.5 Ks (Over +124, Under -158) | 2026 Stats: 5.4 strikeouts per game in 8 appearances

Los Angeles Angels at Seattle Mariners

• Bryce Miller (Mariners): Over/Under 6.5 Ks (Over +116, Under -148) | 2026 Stats: 5.3 strikeouts per game in 21 appearances
• Reid Detmers (Angels): Over/Under 6.5 Ks (Over -113, Under -113) | 2026 Stats: 6.6 strikeouts per game in 31 appearances

Arizona Diamondbacks at San Diego Padres

• Brandon Pfaadt (Diamondbacks): Over/Under 3.5 Ks (Over -132, Under +104) | 2026 Stats: 3.1 strikeouts per game in 28 appearances

Houston Astros at Athletics

• Jacob Lopez (Athletics): Over/Under 4.5 Ks (Over +118, Under -150) | 2026 Stats: 4.2 strikeouts per game in 26 appearances
• Hunter Brown (Astros): Over/Under 5.5 Ks (Over -111, Under -115) | 2026 Stats: 6.3 strikeouts per game in 19 appearances

Baltimore Orioles at New York Yankees

• Brendan Beck (Yankees): Over/Under 4.5 Ks (Over -140, Under +110) | 2026 Stats: 3.2 strikeouts per game in 4 appearances
• Trevor Rogers (Orioles): Over/Under 6.5 Ks (Over +104, Under -132) | 2026 Stats: 5.2 strikeouts per game in 30 appearances

Chicago Cubs at Boston Red Sox

• Clay Holmes (Cubs): Over/Under 3.5 Ks (Over -154, Under +120) | 2026 Stats: 4.3 strikeouts per game in 18 appearances