Louisville vs Indiana College Basketball Prediction, Odds, Picks, Best Bets for Dec. 6

The Indiana Hoosiers (7-1) will look to extend a six-game home winning streak when they host the Louisville Cardinals (7-1) on December 6, 2025 at Gainbridge Fieldhouse.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Indiana Game Info and Odds

• Game day: Saturday, December 6, 2025
• Game time: 2:15 p.m. ET
• TV channel: CBS
• Location: Indianapolis, Indiana
• Arena: Gainbridge Fieldhouse

Check out the betting insights and trends below before placing a wager on Saturday's Louisville-Indiana spread (Louisville -3.5) or total (159.5 points).

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Louisville vs. Indiana: ATS Betting Stats and Trends

• Louisville has covered five times in eight games with a spread this season.
• Indiana is 5-3-0 ATS this year.
• The Cardinals sported a worse record against the spread at home (8-9-0) than they did in away games (9-2-0) last season.
• In 2024-25 against the spread, the Hoosiers had a better winning percentage at home (.556, 10-8-0 record) than away (.500, 5-5-0).

Louisville vs. Indiana: Moneyline Betting Stats

• Louisville has been the moneyline favorite in three games this season and has come away with the win two times (66.7%) in those contests.
• The Cardinals have been listed as a favorite of -172 or more on two occasions this season and won both games.
• Indiana has not played as the moneyline underdog yet this season.
• The Hoosiers have not played a game this season with moneyline odds of +142 or longer.
• Louisville has an implied victory probability of 63.2% according to the moneyline set by sportsbooks for this matchup.

Louisville vs. Indiana Head-to-Head Comparison

• With 78.5 points scored per game and 69.5 points conceded last season, Louisville was 65th in the country offensively and 89th defensively.
• Louisville collected 34.6 rebounds per game and conceded 30.2 boards last year, ranking 47th and 114th, respectively, in college basketball.
• With 13.9 assists per game last season, Louisville was 148th in college basketball.
• Last year, Louisville was 150th in the nation in turnovers committed (10.9 per game) and 93rd in turnovers forced (12.2).
• On offense, Indiana scored 74.7 points per game (147th-ranked in college basketball) last year. It gave up 72 points per contest on defense (182nd-ranked).
• Last season Indiana grabbed 32.7 boards per game (142nd-ranked in college basketball) and gave up 30.3 rebounds per contest (121st-ranked).
• Indiana averaged 15.9 dimes per game, which ranked them 42nd in the nation.
• Indiana ranked 201st in college basketball with 11.3 turnovers per game last season. Meanwhile, it ranked 234th with 10.7 forced turnovers per game.

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