Louisville vs Eastern Michigan College Basketball Prediction, Odds, Picks, Best Bets for Nov. 24

The Louisville Cardinals (5-0) will try to build on a five-game winning streak when they host the Eastern Michigan Eagles (3-2) on November 24, 2025 at KFC Yum! Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Eastern Michigan Game Info and Odds

• Game day: Monday, November 24, 2025
• Game time: 7 p.m. ET
• TV channel: ACC Network
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Before making a wager on Monday's Louisville-Eastern Michigan spread (Louisville -33.5) or over/under (162.5 points), read the betting insights and trends below.

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Louisville vs. Eastern Michigan: ATS Betting Stats and Trends

• Louisville has put together a 3-2-0 record against the spread this season.
• Eastern Michigan has compiled a 4-1-0 ATS record so far this season.
• The Cardinals sported a worse record against the spread at home (8-9-0) than they did in road games (9-2-0) last season.
• In 2024-25 against the spread, the Eagles had a better winning percentage at home (.538, 7-6-0 record) than away (.500, 8-8-0).

Louisville vs. Eastern Michigan Head-to-Head Comparison

• Offensively, Louisville was the 65th-ranked team in the nation (78.5 points per game) last year. Defensively, it was 89th (69.5 points allowed per game).
• With 34.6 rebounds per game and 30.2 rebounds allowed, Louisville was 47th and 114th in college basketball, respectively, last season.
• Last season Louisville was ranked 148th in the nation in assists with 13.9 per game.
• At 10.9 turnovers committed per game and 12.2 turnovers forced last year, Louisville was 150th and 93rd in the country, respectively.
• Eastern Michigan ranked 186th in the nation last season with 73.6 points per game. At the other end of the court, it ranked 304th with 76.5 points allowed per contest.
• Eastern Michigan ranked 318th in college basketball with 29.5 rebounds per game. Meanwhile, it ranked 172nd with 31.1 rebounds allowed per contest.
• Eastern Michigan ranked 268th in the country with 12.4 assists per contest.
• Last season Eastern Michigan committed 12.4 turnovers per game (297th-ranked in college basketball) and forced 11.9 turnovers per contest (121st-ranked).

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