James Madison vs Southern Miss Prediction, Odds, Picks, Best Bets for Week 10 2026

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The college football slate on Thursday includes the James Madison Dukes taking on the Southern Miss Golden Eagles.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

James Madison vs Southern Miss Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: James Madison: (-649) | Southern Miss: (+470)
Spread: James Madison: -14.5 (-110) | Southern Miss: +14.5 (-110)
Total: 58.5 -- Over: (-110) | Under: (-110)

James Madison is 6-3-0 against the spread this season.
James Madison has two wins ATS (2-1) as a 14.5-point or higher favorite in 2026.
There have been five James Madison games (of nine) that hit the over this season.
Southern Miss is 4-4-0 against the spread this season.
Southern Miss has won once ATS (1-1) as a 14.5-point underdog or greater this year.
Southern Miss has played eight games this year, and five of them have hit the over.

All college football win probability predictions and picks are according to numberFire.
Prediction: Dukes win (91.9%)

Southern Miss is an underdog by 14.5 points against James Madison. Southern Miss is -110 to cover the spread, and James Madison is -110.

James Madison versus Southern Miss on Nov. 5 has an over/under of 58.5 points, with the over -110 and the under -110.

James Madison is a -649 favorite on the moneyline, while Southern Miss is a +470 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
James Madison	39.1	2	18.9	42	52.4	9
Southern Miss	26.9	80	31.0	114	54.6	8

Check out even more in-depth James Madison vs. Southern Miss analysis on FanDuel Research.

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