Iowa State vs Syracuse College Basketball Prediction, Odds, Picks, Best Bets for Nov. 26

The Iowa State Cyclones (6-0) will try to extend a six-game win streak when they host the Syracuse Orange (4-2) on November 26, 2025 at MGM Grand Garden Arena.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Syracuse Game Info and Odds

• Game day: Wednesday, November 26, 2025
• Game time: 1 p.m. ET
• TV channel: TNT
• Location: Las Vegas, Nevada
• Arena: MGM Grand Garden Arena

Iowa State vs. Syracuse Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (89.6%)

Before placing a bet on Wednesday's Iowa State-Syracuse spread (Iowa State -10.5) or total (150.5 points), take a look at the betting trends and insights below.

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Iowa State vs. Syracuse: ATS Betting Stats and Trends

• Iowa State has compiled a 4-2-0 record against the spread this season.
• Syracuse has compiled a 4-2-0 record against the spread this year.
• Syracuse covers the spread when it is a 10.5-point underdog or more 100% of the time. That's more often than Iowa State covers as a favorite of 10.5 or more (66.7%).
• At home last season, the Cyclones had a worse record against the spread (9-8-0) compared to their ATS record on the road (7-4-0).
• Last year, the Orange were 9-8-0 at home against the spread (.529 winning percentage). Away, they were 5-6-0 ATS (.455).

Iowa State vs. Syracuse: Moneyline Betting Stats

• Iowa State has been listed as the moneyline favorite three times this season and has come away with a win in all of those games.
• Oddsmakers have given the Cyclones the best odds of winning they have seen this season with a -629 moneyline listed for this contest.
• Syracuse has been the moneyline underdog only two other times so far this season, and it lost both games.
• The Orange have played as a moneyline underdog of +450 or longer in only one game this season, which they lost.
• The moneyline set for this matchup implies Iowa State has a 86.3% chance of walking away with the win.

Iowa State vs. Syracuse Head-to-Head Comparison

• Iowa State has a +152 scoring differential, topping opponents by 25.3 points per game. It is putting up 90.5 points per game to rank 35th in college basketball and is giving up 65.2 per contest to rank 45th in college basketball.
• Tamin Lipsey's team-leading 18.4 points per game ranks 90th in the nation.
• Syracuse has a +98 scoring differential, topping opponents by 16.4 points per game. It is putting up 76.7 points per game, 211th in college basketball, and is allowing 60.3 per contest to rank eighth in college basketball.
• Syracuse's leading scorer, Kiyan Anthony, ranks 623rd in college basketball, putting up 12.5 points per game.
• The Cyclones win the rebound battle by 5.4 boards on average. They record 33.7 rebounds per game, which ranks 191st in college basketball, while their opponents pull down 28.3 per contest.
• Joshua Jefferson averages 8.2 rebounds per game (ranking 87th in college basketball) to lead the Cyclones.
• The Orange lose the rebound battle by an average of 2.3 boards. They are recording 33.5 rebounds per game (203rd in college basketball) compared to their opponents' 35.8.
• William Kyle III is 49th in college basketball with nine rebounds per game, leading the Orange.
• Iowa State's 111.7 points per 100 possessions on offense rank 22nd in college basketball, and the 80.4 points it allows per 100 possessions rank 39th in college basketball.
• The Orange average 96.8 points per 100 possessions on offense (203rd in college basketball), and give up 76.2 points per 100 possessions (eighth in college basketball).

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