Iowa State vs St. John's College Basketball Prediction, Odds, Picks, Best Bets for Nov. 24

The Iowa State Cyclones (4-0) will look to extend a four-game home win streak when they host the St. John's Red Storm (3-1) on November 24, 2025 at Michelob ULTRA Arena.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. St. John's Game Info and Odds

• Game day: Monday, November 24, 2025
• Game time: 4:30 p.m. ET
• TV channel: truTV
• Location: Las Vegas, Nevada
• Arena: Michelob ULTRA Arena

Iowa State vs. St. John's Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (54.4%)

Before you wager on Monday's Iowa State-St. John's spread (Iowa State -2.5) or over/under (158.5 points), take a look at the betting trends and insights below.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Iowa State vs. St. John's: ATS Betting Stats and Trends

• Iowa State won 20 games against the spread last season, while failing to cover 15 times.
• St. John's covered 22 times in 36 games with a spread last year.
• When the spread was set as 2.5 or more last season, Iowa State (17-13) covered a lower percentage of those games when it was the favorite (56.7%) than St. John's (3-0) did as the underdog (100%).
• Against the spread last season, the Cyclones played worse when played at home, covering nine times in 17 home games, and seven times in 11 road games.
• Against the spread last season, the Red Storm had better results on the road (6-4-0) than at home (10-8-0).

Iowa State vs. St. John's: Moneyline Betting Stats

• Iowa State won 19 of the 25 games it was the moneyline favorite last season (76%).
• When playing as a moneyline favorite with odds of -160 or shorter, the Cyclones went 19-5 (79.2%).
• Last season, St. John's won two out of the three games in which it was the underdog.
• The Red Storm played as an underdog of +132 or more twice last season and won both games.
• Iowa State has an implied moneyline win probability of 61.5% in this matchup.

Iowa State vs. St. John's Head-to-Head Comparison

• Iowa State put up 80.3 points per game and gave up 68.3 last year, making them 34th in the country offensively and 61st on defense.
• At 32.7 rebounds per game and 28.3 rebounds allowed, Iowa State was 142nd and 31st in college basketball, respectively, last year.
• With 15 assists per game last year, Iowa State was 77th in the nation.
• Last season, Iowa State was 232nd in the country in turnovers committed (11.6 per game) and 13th-best in turnovers forced (14.4).
• With 78.5 points per game on offense, St. John's was 65th in college basketball last year. Defensively, it gave up 65.8 points per contest, which ranked 27th in college basketball.
• St. John's ranked eighth-best in the nation by pulling down 36.9 rebounds per game. In terms of rebounds allowed, it ranked 182nd in college basketball (31.2 allowed per contest).
• St. John's ranked 53rd in the nation with 15.7 assists per contest.
• St. John's ranked 17th-best in the country by forcing 14.2 turnovers per game. It ranked 98th in college basketball by averaging 10.3 turnovers per contest.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!