Iowa State vs Oklahoma State Prediction, Odds, Picks, Best Bets for Week 14 2025

The college football slate on Saturday includes the Iowa State Cyclones facing the Oklahoma State Cowboys.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

Iowa State vs Oklahoma State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-592) | Oklahoma State: (+440)
• Spread: Iowa State: -13.5 (-106) | Oklahoma State: +13.5 (-114)
• Total: 46.5 -- Over: (-105) | Under: (-115)

Iowa State vs Oklahoma State Betting Trends

• Iowa State is 5-6-0 against the spread this season.
• As a 13.5-point or greater favorite, Iowa State has one win ATS (1-1) this season.
• Iowa State has played 11 games this year, and four of them have hit the over.
• Against the spread, Oklahoma State is 4-7-0 this year.
• Oklahoma State is 4-5 as 13.5-point or bigger underdogs in 2025.
• There have been five Oklahoma State games (out of 11) that hit the over this season.

Iowa State vs Oklahoma State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (92.1%)

Iowa State vs Oklahoma State Point Spread

Iowa State is favored by 13.5 points versus Oklahoma State. Iowa State is -106 to cover the spread, while Oklahoma State is -114.

Iowa State vs Oklahoma State Over/Under

Iowa State versus Oklahoma State, on Nov. 29, has an over/under of 46.5, with the over being -105 and the under -115.

Iowa State vs Oklahoma State Moneyline

Iowa State is a -592 favorite on the moneyline, while Oklahoma State is a +440 underdog.

Iowa State vs. Oklahoma State Points Insights

Iowa State vs. Oklahoma State Game Info

• Game day: Saturday, November 29, 2025
• Game time: 12 p.m. ET
• TV channel: ESPNU
• Location: Stillwater, Oklahoma
• Stadium: Boone Pickens Stadium

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