Iowa State vs Oklahoma State College Basketball Prediction, Odds, Picks, Best Bets for Jan. 10

The Iowa State Cyclones (15-0, 2-0 Big 12) aim to build on a 12-game home win streak when they host the Oklahoma State Cowboys (13-2, 1-1 Big 12) on January 10, 2026.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Oklahoma State Game Info and Odds

• Game day: Saturday, January 10, 2026
• Game time: 4 p.m. ET
• TV channel: ESPN2
• Location: Ames, Iowa
• Arena: James H. Hilton Coliseum

Iowa State vs. Oklahoma State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (85.7%)

See the betting insights and trends below before making a wager on Saturday's Iowa State-Oklahoma State spread (Iowa State -18.5) or over/under (164.5 points).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Iowa State vs. Oklahoma State: ATS Betting Stats and Trends

• Iowa State has compiled a 9-6-0 ATS record so far this year.
• Oklahoma State has covered seven times in 15 chances against the spread this season.
• The Cyclones did a better job covering the spread in away games (7-4-0) than they did in home games (9-8-0) last year.
• The Cowboys' winning percentage against the spread at home was .467 (7-8-0) last year. On the road, it was .500 (6-6-0).

Iowa State vs. Oklahoma State: Moneyline Betting Stats

• Iowa State has been listed as the moneyline favorite 10 times this season and has come away with a win in all of those games.
• The Cyclones have been a -4000 moneyline favorite on three occasions this season and won every game.
• Oklahoma State has won 50% of the games this season it was the underdog on the moneyline (2-2).
• The Cowboys have yet to play as a moneyline underdog of +1400 or longer.
• The moneyline set for this matchup implies Iowa State has a 97.6% chance of coming away with a victory in the contest.

Iowa State vs. Oklahoma State Head-to-Head Comparison

• Iowa State has a +389 scoring differential, topping opponents by 25.9 points per game. It is putting up 88.3 points per game to rank 22nd in college basketball and is giving up 62.4 per contest to rank sixth in college basketball.
• Iowa State's leading scorer, Joshua Jefferson, ranks 92nd in the nation putting up 17.6 points per game.
• Oklahoma State puts up 90.2 points per game (17th in college basketball) while allowing 79.7 per outing (318th in college basketball). It has a +157 scoring differential and outscores opponents by 10.5 points per game.
• Oklahoma State's leading scorer, Anthony Roy, ranks 96th in the country, scoring 17.5 points per game.
• The 33.7 rebounds per game the Cyclones average rank 148th in the country, and are 7.0 more than the 26.7 their opponents collect per contest.
• Jefferson averages 7.9 rebounds per game (ranking 84th in college basketball) to lead the Cyclones.
• The 36.2 rebounds per game the Cowboys accumulate rank 53rd in the nation, 4.6 more than the 31.6 their opponents record.
• Parsa Fallah is 326th in the nation with 5.9 rebounds per game, leading the Cowboys.
• Iowa State's 111.8 points per 100 possessions on offense rank sixth in college basketball, and the 78.9 points it allows per 100 possessions rank second in college basketball.
• The Cowboys' 104 points per 100 possessions on offense rank 67th in college basketball, and the 91.9 points they allow per 100 possessions rank 166th in college basketball.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!