Iowa State vs Kansas Prediction, Odds, Picks, Best Bets for Week 13 2025

The Iowa State Cyclones will face the Kansas Jayhawks in college football action on Saturday.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Iowa State vs Kansas Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-164) | Kansas: (+138)
• Spread: Iowa State: -3.5 (-105) | Kansas: +3.5 (-115)
• Total: 55.5 -- Over: (-105) | Under: (-115)

Iowa State vs Kansas Betting Trends

• Iowa State has four wins in 10 games against the spread this season.
• Iowa State has two wins ATS (2-3) as a 3.5-point or higher favorite in 2025.
• Iowa State has played 10 games this season, and four of them have gone over the total.
• Against the spread, Kansas is 4-6-0 this season.
• As a 3.5-point underdog or greater, Kansas has one win ATS (1-2) this season.
• Of 10 Kansas games so far this season, five have hit the over.

Iowa State vs Kansas Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cyclones win (59%)

Iowa State vs Kansas Point Spread

Kansas is an underdog by 3.5 points versus Iowa State. Kansas is -115 to cover the spread, and Iowa State is -105.

Iowa State vs Kansas Over/Under

Iowa State versus Kansas, on Nov. 22, has an over/under of 55.5, with the over being -105 and the under -115.

Iowa State vs Kansas Moneyline

Iowa State is the favorite, -164 on the moneyline, while Kansas is a +138 underdog.

Iowa State vs. Kansas Points Insights

Iowa State vs. Kansas Game Info

• Game day: Saturday, November 22, 2025
• Game time: 12 p.m. ET
• TV channel: Fox Sports 1
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. Kansas analysis on FanDuel Research.