Illinois vs Purdue Prediction, Odds, Picks, Best Bets for Week 5 2026

College football's Saturday slate includes the Illinois Fighting Illini facing the Purdue Boilermakers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

Illinois vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-365) | Purdue: (+290)
• Spread: Illinois: -10.5 (-102) | Purdue: +10.5 (-120)
• Total: 62.5 -- Over: (-106) | Under: (-114)

Illinois vs Purdue Betting Trends

• Illinois has won twice against the spread this year.
• Illinois owns one win ATS (1-1) as a 10.5-point favorite or greater this year.
• Illinois and its opponent have not failed to hit the over in any game this season.
• Purdue has posted one win against the spread this year.
• Purdue doesn't have a win ATS (0-2) as a 10.5-point underdog or greater this year.
• All four Purdue games have gone over the point total this season.

Illinois vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (86.5%)

Illinois vs Purdue Point Spread

Purdue is an underdog by 10.5 points against Illinois. Purdue is -120 to cover the spread, and Illinois is -102.

Illinois vs Purdue Over/Under

An over/under of 62.5 has been set for Illinois-Purdue on Oct. 3, with the over being -106 and the under -114.

Illinois vs Purdue Moneyline

Looking at the moneyline for Illinois-Purdue, Illinois is the favorite at -365, and Purdue is +290.

Illinois vs. Purdue Points Insights

Illinois vs. Purdue Game Info

• Game day: Saturday, October 3, 2026
• Game time: 4:15 p.m. ET
• TV channel: BTN
• Location: Champaign, Illinois
• Stadium: Gies Memorial Stadium (Champaign, IL)

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