Illinois vs Purdue Prediction, Odds, Picks, Best Bets for Week 5 2026

The Illinois Fighting Illini will take on the Purdue Boilermakers in college football action on Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Illinois vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-410) | Purdue: (+315)
• Spread: Illinois: -10.5 (-102) | Purdue: +10.5 (-120)
• Total: 61.5 -- Over: (-110) | Under: (-110)

Illinois vs Purdue Betting Trends

• Illinois has posted two wins against the spread this season.
• As a 10.5-point or greater favorite, Illinois has one win ATS (1-1) this season.
• Every Illinois game has hit the over this season.
• Purdue has posted one win against the spread this year.
• Purdue doesn't have a win ATS (0-2) as a 10.5-point underdog or greater this season.
• Every Purdue game has hit the over this year.

Illinois vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (86%)

Illinois vs Purdue Point Spread

Purdue is an underdog by 10.5 points versus Illinois. Purdue is -120 to cover the spread, and Illinois is -102.

Illinois vs Purdue Over/Under

The over/under for the Illinois versus Purdue matchup on Oct. 3 has been set at 61.5, with -110 odds on the over and -110 odds on the under.

Illinois vs Purdue Moneyline

The moneyline numbers for Illinois vs. Purdue reveal Illinois as the favorite (-410) and Purdue as the underdog (+315).

Illinois vs. Purdue Points Insights

Illinois vs. Purdue Game Info

• Game day: Saturday, October 3, 2026
• Game time: 4:15 p.m. ET
• TV channel: BTN
• Location: Champaign, Illinois
• Stadium: Gies Memorial Stadium (Champaign, IL)

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Check out even more in-depth Illinois vs. Purdue analysis on FanDuel Research.