Illinois vs Duke Prediction, Odds, Picks, Best Bets for Week 2 2026

On Saturday in college football, the Illinois Fighting Illini are up against the Duke Blue Devils.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Illinois vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-235) | Duke: (+190)
• Spread: Illinois: -5.5 (-115) | Duke: +5.5 (-105)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Illinois vs Duke Betting Trends

• Illinois has no wins against the spread this season.
• Illinois has no wins ATS (0-1) as a 5.5-point favorite or greater this year.
• Illinois and its opponent have not failed to hit the over in any game this season.
• Duke has but one win versus the spread this year.
• Duke and its opponent have yet to hit the over this season.

Illinois vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (75.6%)

Illinois vs Duke Point Spread

Illinois is favored by 5.5 points over Duke. Illinois is -115 to cover the spread, with Duke being -105.

Illinois vs Duke Over/Under

A total of 51.5 points has been set for the Illinois-Duke game on Sept. 12, with the over available at -110 and the under at -110.

Illinois vs Duke Moneyline

Looking at the moneyline for Illinois-Duke, Illinois is the favorite at -235, and Duke is +190.

Illinois vs. Duke Points Insights

• The Fighting Illini had an average implied point total of 33.4 last season, which is 4.4 points higher than their implied total in Saturday's game (29).
• The Blue Devils' average implied point total last season (30.9 points) is 7.9 points higher than their implied total in this matchup (23 points).

Illinois vs. Duke Game Info

• Game day: Saturday, September 12, 2026
• Game time: 3:30 p.m. ET
• TV channel: Fox Sports 1
• Location: Champaign, Illinois
• Stadium: Gies Memorial Stadium (Champaign, IL)

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Check out even more in-depth Illinois vs. Duke analysis on FanDuel Research.