Illinois vs Duke Prediction, Odds, Picks, Best Bets for Week 2 2026

Saturday's slate in college football includes a matchup between the Illinois Fighting Illini and the Duke Blue Devils.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Illinois vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-225) | Duke: (+184)
• Spread: Illinois: -5.5 (-115) | Duke: +5.5 (-105)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Illinois vs Duke Betting Trends

• Illinois has no wins against the spread this season.
• Illinois is winless ATS (0-1) as a 5.5-point favorite or greater this season.
• One of Illinois' one games this season has hit the over.
• Duke hasn't lost a game against the spread this season.
• No Duke game has gone over the point total this year.

Illinois vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (75%)

Illinois vs Duke Point Spread

Duke is a 5.5-point underdog against Illinois. Duke is -105 to cover the spread, and Illinois is -115.

Illinois vs Duke Over/Under

The over/under for the Illinois versus Duke matchup on Sept. 12 has been set at 51.5, with -110 odds on the over and -110 odds on the under.

Illinois vs Duke Moneyline

Duke is the underdog, +184 on the moneyline, while Illinois is a -225 favorite.

Illinois vs. Duke Points Insights

• The Fighting Illini's average implied point total last season was 4.4 more points than their implied total in Saturday's game (33.4 implied points on average compared to 29 implied points in this game).
• The average implied point total last season for the Blue Devils (30.9) is 7.9 more points than the team's implied total in this matchup (23).

Illinois vs. Duke Game Info

• Game day: Saturday, September 12, 2026
• Game time: 3:30 p.m. ET
• TV channel: Fox Sports 1
• Location: Champaign, Illinois
• Stadium: Gies Memorial Stadium (Champaign, IL)

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Check out even more in-depth Illinois vs. Duke analysis on FanDuel Research.