Pirates vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 7:12 p.m.

The MLB schedule on Thursday includes the Chicago White Sox taking on the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

White Sox vs Pirates Game Info

• Chicago White Sox (75-70) vs. Pittsburgh Pirates (73-73)
• Date: Thursday, September 10, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SportsNet PT

White Sox vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-112) | PIT: (-104)
• Spread: CHW: +1.5 (-205) | PIT: -1.5 (+168)
• Total: 7.5 -- Over: (-115) | Under: (-105)

White Sox vs Pirates Probable Starting Pitchers

Probable Pitchers: Hagen Smith (White Sox) - 3-1, 0.56 ERA vs Jared Jones (Pirates) - 3-6, 4.46 ERA

The White Sox will give the nod to Hagen Smith (3-1, 0.56 ERA), who is eyeing win No. 4 on the season, and the Pirates will turn to Jared Jones (3-6, 4.46 ERA). Smith did not appear in a game when his team was the moneyline favorite last season. When Jones starts, the Pirates are 7-10-0 against the spread. The Pirates are 4-5 in Jones' nine starts this season that they were the moneyline underdog.

White Sox vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (52.1%)

White Sox vs Pirates Moneyline

• Chicago is the favorite, -112 on the moneyline, while Pittsburgh is a -104 underdog on the road.

White Sox vs Pirates Spread

• The Pirates are 1.5-run favorites against the spread for this matchup with the White Sox. The Pirates are +168 to cover, while the White Sox are -205 to cover as a 1.5-run underdog on the runline.

White Sox vs Pirates Over/Under

• An over/under of 7.5 has been set for White Sox-Pirates on Sept. 10, with the over being -115 and the under -105.

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White Sox vs Pirates Betting Trends

• The White Sox have been chosen as favorites in 34 games this year and have walked away with the win 19 times (55.9%) in those games.
• Chicago has a record of 18-14 in contests when sportsbooks favor them by -112 or more on the moneyline.
• The White Sox and their opponents have gone over the total this season in 78 of their 142 opportunities.
• In 142 games with a line this season, the White Sox have a mark of 81-61-0 against the spread.
• The Pirates have been the moneyline underdog 66 total times this season. They've gone 29-37 in those games.
• Pittsburgh has gone 25-33 in games it has played as a moneyline underdog with odds of -104 or longer (43.1%).
• The Pirates have had an over/under set by oddsmakers 144 times, and have combined with opponents to go over the total in 75 of those games (75-65-4).
• The Pirates have a 69-75-0 record ATS this season.

White Sox Player Leaders

• Miguel Vargas is hitting .249 with 30 doubles, a triple, 30 home runs and 87 walks. He has an on-base percentage of .359 and a slugging percentage of .479.
• Among all qualifying hitters in MLB, his batting average ranks 77th, his on-base percentage ranks 32nd, and he is 25th in slugging.
• Sam Antonacci leads Chicago with an OBP of .365 this season while batting .267 with 42 walks and 72 runs scored. He's slugging .390.
• Among qualifying hitters, his batting average ranks him 46th, his on-base percentage 23rd, and his slugging percentage 100th.
• Antonacci heads into this game looking to extend his three-game hit streak. In his last five games he is hitting .316 with three doubles, two walks and three RBIs.
• Tristan Peters has collected 112 base hits, an OBP of .347 and a slugging percentage of .470 this season.
• Chase Meidroth has an OPS of .734, fueled by an OBP of .343 and a team-best slugging percentage of .391 this season.

Pirates Player Leaders

• Bryan Reynolds has put up an on-base percentage of .371, a team-best for the Pirates. He's batting .266 and slugging .429.
• Including all the qualified hitters in the majors, his batting average ranks 51st, his on-base percentage is 13th, and he is 63rd in slugging.
• Brandon Lowe has racked up 138 hits to lead his team. He has a batting average of .259 while slugging .479 with an on-base percentage of .328.
• Including all qualifying hitters, his batting average places him 62nd, his on-base percentage ranks 70th, and he is 25th in slugging.
• Nick Gonzales has put up a slugging percentage of .392, a team-best for the Pirates.
• Oneil Cruz is hitting .270 with 12 doubles, a triple, 17 home runs and 41 walks.

White Sox vs Pirates Head to Head

• 9/9/2026: 4-2 PIT (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/8/2026: 9-3 PIT (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/20/2025: 7-2 CHW (Favorite: Pirates, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/19/2025: 10-4 CHW (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/18/2025: 10-1 CHW (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/14/2024: 9-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 7/13/2024: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2024: 4-1 PIT (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/9/2023: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/8/2023: 11-5 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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