Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 6:12 p.m.

In MLB action on Monday, the Cleveland Guardians face the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-74) vs. Chicago White Sox (76-73)
• Date: Monday, September 14, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-162) | CHW: (+136)
• Spread: CLE: -1.5 (+134) | CHW: +1.5 (-162)
• Total: 6.5 -- Over: (-134) | Under: (+110)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-7, 3.78 ERA vs Sean Newcomb (White Sox) - 2-4, 2.77 ERA

The Guardians will give the nod to Gavin Williams (13-7) against the White Sox and Sean Newcomb (2-4). Williams and his team have a record of 14-14-0 against the spread when he starts. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 14-9. The White Sox are 3-2-0 ATS in Newcomb's five starts that had a set spread. The White Sox have been the underdog on the moneyline in three of Newcomb's starts this season, and they went 2-1 in those games.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.2%)

Guardians vs White Sox Moneyline

• Looking at the moneyline for White Sox-Guardians, Chicago is the underdog at +136, and Cleveland is -162 playing at home.

Guardians vs White Sox Spread

• The Guardians are hosting the White Sox and are favored by 1.5 runs on the spread. The Guardians are +134 to cover the runline, with the White Sox being -162.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox game on Sept. 14 has been set at 6.5, with -134 odds on the over and +110 odds on the under.

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Guardians vs White Sox Betting Trends

• The Guardians have been favorites in 84 games this season and have come away with the win 43 times (51.2%) in those contests.
• Cleveland has a record of 10-5 in contests when oddsmakers favor them by -162 or more on the moneyline.
• The Guardians and their opponents have gone over the total this season in 69 of their 142 opportunities.
• The Guardians have posted a record of 67-75-0 against the spread this season.
• The White Sox have won 48% of the games this season they were the moneyline underdog (49-53).
• Chicago has a 7-15 record (winning just 31.8% of its games) when playing as a moneyline underdog of +136 or longer.
• The White Sox have had an over/under set by bookmakers 146 times, and have combined with opponents to go over the total in 80 of those games (80-65-1).
• The White Sox have collected an 81-65-0 record against the spread this season (covering 55.5% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 134 hits, batting .291 this season with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .456.
• Among all qualifying hitters in baseball, he is 12th in batting average, 25th in on-base percentage, and 42nd in slugging.
• Steven Kwan leads the Guardians with an OPS of .721. He has a slash line of .278/.375/.346 this season.
• Among qualified hitters, he is 26th in batting average, 10th in on-base percentage and 130th in slugging percentage.
• Kwan has picked up at least one hit in seven games in a row. During his last 10 outings he is batting .317 with four doubles, a home run, four walks and three RBIs.
• Jose Ramirez is batting .230 with a .363 slugging percentage and 48 RBI this year.
• Brayan Rocchio has been key for Cleveland with 123 hits, an OBP of .306 plus a slugging percentage of .374.

White Sox Player Leaders

• Miguel Vargas leads the White Sox with 135 hits. He's batting .247 and slugging .470 with an on-base percentage of .355.
• Including all the qualifying hitters in the big leagues, his batting average places him 85th, his on-base percentage ranks 38th, and he is 31st in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .150 with a walk.
• Sam Antonacci's .366 on-base percentage leads his team. He has a batting average of .269 while slugging .393.
• Including all qualified hitters, his batting average puts him 43rd, his on-base percentage is 20th, and he is 97th in slugging.
• Chase Meidroth has a .398 slugging percentage, which leads the White Sox.
• Tristan Peters has 31 doubles, four triples, 12 home runs and 34 walks while hitting .279.

Guardians vs White Sox Head to Head

• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/22/2026: 6-5 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/14/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

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