Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 5 on Oct. 10

Odds updated as of 7:12 a.m.

The Cleveland Guardians versus the Chicago White Sox in Game 5 of the ALDS is on the MLB schedule for Saturday.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Saturday, October 10, 2026
• Time: 8 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: TBS, truTV, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | CHW: (+118)
• Spread: CLE: -1.5 (+164) | CHW: +1.5 (-200)
• Total: 7.5 -- Over: (+110) | Under: (-134)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 14-8, 3.76 ERA vs Sean Burke (White Sox) - 11-7, 3.34 ERA

The probable starters are Gavin Williams (14-8, 3.76 ERA) for the Guardians and Sean Burke (11-7, 3.34 ERA) for the White Sox. Williams and his team have a record of 14-16-0 against the spread when he starts. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 14-11. The White Sox have a 16-12-0 ATS record in Burke's 28 starts with a set spread. The White Sox have been the moneyline underdog in 16 of Burke's starts this season, and they went 7-9 in those matchups.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.8%)

Guardians vs White Sox Moneyline

• The Guardians vs White Sox moneyline has Cleveland as a -138 favorite, while Chicago is a +118 underdog on the road.

Guardians vs White Sox Spread

• The White Sox are +1.5 on the spread (-200 to cover), and Cleveland is +164 to cover the runline.

Guardians vs White Sox Over/Under

• The over/under for Guardians-White Sox on Oct. 10 is 7.5. The over is +110, and the under is -134.

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Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 93 games this year and have walked away with the win 49 times (52.7%) in those games.
• This season Cleveland has come away with a win 25 times in 40 chances when named as a favorite of at least -138 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 77 of their 156 opportunities.
• The Guardians have an against the spread record of 75-81-0 in 156 games with a line this season.
• The White Sox have won 54 of the 110 games they were the moneyline underdog this season (49.1%).
• Chicago has a 30-36 record (winning 45.5% of its games) when playing as a moneyline underdog of +118 or longer.
• The White Sox have played in 165 games with a set over/under, and have combined with opponents to go over the total 94 times (94-70-1).
• The White Sox have covered 57% of their games this season, going 94-71-0 ATS.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (142) this season while batting .287 with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among the qualifying batters in the majors, his batting average ranks 16th, his on-base percentage ranks 24th, and he is 43rd in slugging.
• DeLauter will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .250 with a home run, three walks and three RBIs.
• Steven Kwan is slashing .282/.382/.349 this season and leads the Guardians with an OPS of .731.
• He ranks 21st in batting average, seventh in on-base percentage and 131st in slugging in the major leagues.
• Kwan brings a three-game streak with at least one hit into this matchup. During his last five outings he is batting .300 with a triple, four walks and two RBIs.
• Jose Ramirez has 111 hits this season and has a slash line of .235/.320/.368.
• Ramirez has picked up a hit in two games in a row. In his last five games he is batting .200 with a double, a triple, a home run, three walks and five RBIs.
• Brayan Rocchio is batting .253 with a .313 OBP and 73 RBI for Cleveland this season.

White Sox Player Leaders

• Miguel Vargas has 31 doubles, a triple, 33 home runs and 101 walks while hitting .250. He's slugging .474 with an on-base percentage of .363.
• Including all qualified hitters in MLB, his batting average places him 79th, his on-base percentage ranks 24th, and he is 30th in slugging.
• Vargas heads into this game on a four-game hitting streak. In his last five games he is batting .267 with a home run, eight walks and an RBI.
• Chase Meidroth paces his team with a .415 slugging percentage. He has a batting average of .276 with an on-base percentage of .350.
• His batting average ranks 33rd among all qualified players, his on-base percentage is 45th, and he is 80th in slugging.
• Sam Antonacci a has .370 on-base percentage to pace the White Sox.
• Munetaka Murakami's 94 hits pace his team.

Guardians vs White Sox Head to Head

• 10/8/2026: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -114, Underdog Moneyline: +100)
• 10/7/2026: 9-3 CLE (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -128, Underdog Moneyline: +112)
• 10/5/2026: 4-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +136)
• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)

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