Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 5:11 p.m.

In MLB action on Saturday, the Cleveland Guardians take on the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Guardians vs Athletics Game Info

• Cleveland Guardians (79-75) vs. Athletics (61-93)
• Date: Saturday, September 19, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-178) | OAK: (+150)
• Spread: CLE: -1.5 (+120) | OAK: +1.5 (-144)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 6-15, 4.16 ERA vs Jacob Lopez (Athletics) - 6-4, 5.02 ERA

The Guardians will look to Tanner Bibee (6-15) versus the Athletics and Jacob Lopez (6-4). When Bibee starts, his team is 8-21-0 against the spread this season. Bibee's team has won 28.6% of his starts when they are favored on the moneyline (4-10). The Athletics have gone 13-9-0 ATS in Lopez's 22 starts that had a set spread. The Athletics are 11-9 in Lopez's 20 starts this season that they were the moneyline underdog.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.4%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -178 favorite, while the Athletics are a +150 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +120 to cover, while the Athletics are -144 to cover.

Guardians vs Athletics Over/Under

• Guardians versus Athletics on Sept. 19 has an over/under of 7.5 runs, with the odds on the over -118 and the under set at -104.

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Guardians vs Athletics Betting Trends

• The Guardians have been chosen as favorites in 88 games this year and have walked away with the win 46 times (52.3%) in those games.
• This year, the Guardians have won six of nine games when listed as at least -178 or better on the moneyline.
• The Guardians and their opponents have hit the over in 72 of their 146 games with a total this season.
• In 146 games with a line this season, the Guardians have a mark of 69-77-0 against the spread.
• The Athletics have won 38.5% of the games this season they were the underdog on the moneyline (45-72).
• The Athletics have a record of 10-22 when they have played as a moneyline underdog with odds of +150 or longer (31.2%).
• The Athletics have played in 154 games with an over/under set, and have combined with their opponents to go over the total 79 times (79-73-2).
• The Athletics have covered 47.4% of their games this season, going 73-81-0 against the spread.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 135 hits, batting .289 this season with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .452.
• Among qualified hitters, he ranks 12th in batting average, his on-base percentage ranks 25th, and he is 43rd in slugging.
• Steven Kwan has a slash line of .275/.376/.342 this season and a team-best OPS of .717.
• Among all qualifying players, he is 34th in batting average, 12th in on-base percentage and 131st in slugging percentage.
• Jose Ramirez is batting .232 with a .372 slugging percentage and 51 RBI this year.
• Ramirez has logged a hit or more in two games in a row. In his last five games he is hitting .238 with two doubles, a home run and three RBIs.
• Brayan Rocchio is batting .250 with a .312 OBP and 69 RBI for Cleveland this season.

Athletics Player Leaders

• Jeff McNeil has put up a slugging percentage of .369, a team-high for the Athletics. He's batting .268 with an on-base percentage of .315.
• Including all the qualified hitters in the big leagues, his batting average ranks 46th, his on-base percentage is 95th, and he is 117th in slugging.
• Shea Langeliers is batting .263 with 19 doubles, 23 home runs and 34 walks. He's slugging .487 with an on-base percentage of .329.
• Zack Gelof is batting .247 with 15 doubles, two triples, 19 home runs and 29 walks.
• Lawrence Butler's 101 hits and .321 on-base percentage both pace his team.

Guardians vs Athletics Head to Head

• 9/18/2026: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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