Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 1:11 a.m.

The Saturday slate in MLB includes a matchup between the Cleveland Guardians and the Athletics.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Athletics Game Info

• Cleveland Guardians (79-75) vs. Athletics (61-93)
• Date: Saturday, September 19, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-178) | OAK: (+150)
• Spread: CLE: -1.5 (+128) | OAK: +1.5 (-154)
• Total: 7.5 -- Over: (-132) | Under: (+108)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 6-15, 4.16 ERA vs Jacob Lopez (Athletics) - 6-4, 5.02 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (6-15) to the mound, while Jacob Lopez (6-4) will get the nod for the Athletics. When Bibee starts, his team is 8-21-0 against the spread this season. Bibee's team has been victorious in 28.6% of the games he's started as the moneyline favorite with a record of 4-10. The Athletics have gone 13-9-0 ATS in Lopez's 22 starts that had a set spread. The Athletics have been the moneyline underdog in 20 of Lopez's starts this season, and they went 11-9 in those matchups.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.9%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -178 favorite, while the Athletics are a +150 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +128 to cover, while the Athletics are -154 to cover.

Guardians vs Athletics Over/Under

• The over/under for the Guardians versus Athletics game on Sept. 19 has been set at 7.5, with -132 odds on the over and +108 odds on the under.

Bet on Cleveland Guardians vs. Athletics on FanDuel today!

Guardians vs Athletics Betting Trends

• The Guardians have come away with 46 wins in the 88 contests they have been listed as the favorites in this season.
• This season, the Guardians have come away with a win six times in nine chances when named as a favorite of at least -178 or better on the moneyline.
• The Guardians and their opponents have hit the over in 72 of their 146 games with a total this season.
• The Guardians are 69-77-0 against the spread in their 146 games with a line set by sportsbooks this season.
• The Athletics are 45-72 in games they were the underdog on the moneyline (winning 38.5% of those games).
• When playing as a moneyline underdog with odds of +150 or longer, the Athletics have a record of 10-22 (31.2%).
• The Athletics have played in 154 games with an over/under set, and have combined with their opponents to go over the total 79 times (79-73-2).
• The Athletics have covered 47.4% of their games this season, going 73-81-0 ATS.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (135) this season while batting .289 with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .452.
• Among all qualified hitters in the majors, he ranks 12th in batting average, 25th in on-base percentage, and 44th in slugging.
• Steven Kwan is slashing .275/.376/.342 this season and leads the Guardians with an OPS of .717.
• Among all qualifying batters, he ranks 35th in batting average, 12th in on-base percentage and 131st in slugging percentage.
• Jose Ramirez has collected 103 base hits, an OBP of .320 and a slugging percentage of .372 this season.
• Ramirez heads into this game with two games in a row with at least one hit. In his last five games he is hitting .238 with two doubles, a home run and three RBIs.
• Brayan Rocchio is batting .250 with a .312 OBP and 69 RBI for Cleveland this season.

Athletics Player Leaders

• Jeff McNeil has a .369 slugging percentage, which leads the Athletics. He's batting .268 with an on-base percentage of .315.
• Including all the qualifying hitters in MLB, he ranks 46th in batting average, 96th in on-base percentage and 117th in slugging percentage.
• Shea Langeliers has 19 doubles, 23 home runs and 34 walks while hitting .263. He's slugging .487 with an on-base percentage of .329.
• Lawrence Butler has a team-best OBP (.321), while pacing the Athletics in hits (101).
• Zack Gelof is hitting .247 with 15 doubles, two triples, 19 home runs and 29 walks.

Guardians vs Athletics Head to Head

• 9/18/2026: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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