Golden Knights vs Blues NHL Prediction, Odds, Picks, Best Bets for Oct. 22

The NHL schedule on Thursday includes the Vegas Golden Knights facing the St. Louis Blues.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NHL betting insights.

Golden Knights vs Blues Game Info

• Vegas Golden Knights (8-3) vs. St. Louis Blues (4-4-1)
• Date: Thursday, October 22, 2026
• Time: 8 p.m. ET
• Venue: Enterprise Center -- St. Louis, Missouri
• Coverage: ESPN+

Golden Knights vs Blues Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Golden Knights vs Blues Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Golden Knights win (51.4%)

Golden Knights vs Blues Puck Line

• The Golden Knights are favored by 1.5 goals (+198 to cover). St. Louis, the underdog, is -250.

Golden Knights vs Blues Over/Under

• An over/under of 5.5 has been set for Golden Knights-Blues on Oct. 22, with the over being -140 and the under +114.

Golden Knights vs Blues Moneyline

• The Golden Knights vs Blues moneyline has Vegas as a -122 favorite, while St. Louis is a +102 underdog at home.

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