Florida vs Missouri Prediction, Odds, Picks, Best Bets for Week 5 2026

The Florida Gators will take on the Missouri Tigers in college football action on Saturday.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Florida vs Missouri Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida: (-220) | Missouri: (+180)
• Spread: Florida: -5.5 (-108) | Missouri: +5.5 (-112)
• Total: 57.5 -- Over: (-115) | Under: (-105)

Florida vs Missouri Betting Trends

• Florida is 3-1-0 against the spread this season.
• As a 5.5-point or greater favorite, Florida has one win ATS (1-1) this season.
• Florida has played four games this year, and three of them have hit the over.
• Missouri has but one win versus the spread this season.
• A pair of Missouri four games in 2026 have gone over the point total.

Florida vs Missouri Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (52.9%)

Florida vs Missouri Point Spread

Florida is favored by 5.5 points versus Missouri. Florida is -108 to cover the spread, while Missouri is -112.

Florida vs Missouri Over/Under

Florida versus Missouri on Oct. 3 has an over/under of 57.5 points, with the over -115 and the under -105.

Florida vs Missouri Moneyline

Missouri is the underdog, +180 on the moneyline, while Florida is a -220 favorite.

Florida vs. Missouri Points Insights

Florida vs. Missouri Game Info

• Game day: Saturday, October 3, 2026
• Game time: 3:30 p.m. ET
• TV channel: ABC
• Location: Columbia, Missouri
• Stadium: Memorial Stadium/Faurot Field

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Check out even more in-depth Florida vs. Missouri analysis on FanDuel Research.