Florida International vs Buffalo Prediction, Odds, Picks, Best Bets for Week 2 2026

The Florida International Panthers will take on the Buffalo Bulls in college football action on Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

Florida International vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida International: (-420) | Buffalo: (+320)
• Spread: Florida International: -10.5 (-108) | Buffalo: +10.5 (-112)
• Total: 47.5 -- Over: (-115) | Under: (-105)

Florida International vs Buffalo Betting Trends

• Florida International has one win against the spread this season.
• Buffalo is winless against the spread this year.
• No Buffalo game has gone over the point total this year.

Florida International vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Panthers win (66.8%)

Florida International vs Buffalo Point Spread

Buffalo is an underdog by 10.5 points against Florida International. Buffalo is -112 to cover the spread, and Florida International is -108.

Florida International vs Buffalo Over/Under

A total of 47.5 points has been set for the Florida International-Buffalo matchup on Sept. 12, with the over available at -115 and the under at -105.

Florida International vs Buffalo Moneyline

The Florida International vs Buffalo moneyline has Florida International as a -420 favorite, while Buffalo is a +320 underdog.

Florida International vs. Buffalo Points Insights

• The average implied total for the Panthers last season was 31.8 points, 2.8 more points than their implied total of 29 points in Saturday's game.
• The average implied point total last season for the Bulls (29.0) is 10.0 more points than the team's implied total in this matchup (19).

Florida International vs. Buffalo Game Info

• Game day: Saturday, September 12, 2026
• Game time: 6 p.m. ET
• TV channel: ESPN+
• Location: Miami, Florida
• Stadium: Pitbull Stadium

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Check out even more in-depth Florida International vs. Buffalo analysis on FanDuel Research.