Duke vs Syracuse College Basketball Prediction, Odds, Picks, Best Bets for Feb. 16

The Syracuse Orange (15-11, 6-7 ACC) aim to stop a four-game road losing streak when they visit the Duke Blue Devils (23-2, 12-1 ACC) on February 16, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Syracuse Game Info and Odds

• Game day: Monday, February 16, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Check out these betting insights and trends before you bet on Monday's Duke-Syracuse spread (Duke -20.5) or total (144.5 points).

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Duke vs. Syracuse: ATS Betting Stats and Trends

• Duke has covered 12 times in 25 games with a spread this season.
• Syracuse has won 14 games against the spread this year, while failing to cover 12 times.
• In home games, the Blue Devils own a worse record against the spread (4-8-0) compared to their ATS record in away games (6-3-0).
• This year, the Orange are 8-8-0 at home against the spread (.500 winning percentage). On the road, they are 4-2-0 ATS (.667).
• Against the spread, in conference action, Duke is 6-7-0 this season.
• Syracuse is 8-5-0 against the spread in ACC play this year.

Duke vs. Syracuse: Moneyline Betting Stats

• Duke has been victorious in 17, or 89.5%, of the 19 contests it has been chosen as moneyline favorites in this season.
• The Blue Devils have been listed as a favorite of -4545 or more on two occasions this season and won both games.
• Syracuse has gone 3-8 in games it was the underdog on the moneyline (winning 27.3% of those games).
• The Orange have not played a game this season with moneyline odds of +1600 or longer.
• Duke has an implied victory probability of 97.8% according to the moneyline set for this matchup.

Duke vs. Syracuse Head-to-Head Comparison

• Offensively, Duke was the 11th-best team in the country (83.2 points per game) last year. On defense, it was seventh-best (62.8 points allowed per game).
• On the glass, Duke was 24th-best in college basketball in rebounds (35.6 per game) last year. It was 12th-best in rebounds allowed (27.3 per game).
• With 16.9 assists per game, Duke was 17th-best in the country last year.
• Last season, Duke was ninth-best in college basketball in turnovers committed (8.9 per game) and ranked 265th in turnovers forced (10.4).
• Last season Syracuse put up 74.7 points per game (147th-ranked in college basketball) and ceded 77.8 points per contest (322nd-ranked).
• With 33.6 rebounds per game, Syracuse ranked 75th in college basketball. It allowed 31.1 rebounds per contest, which ranked 172nd in college basketball.
• Syracuse delivered 13.6 dimes per game, which ranked them 174th in college basketball.
• Syracuse, who ranked 259th in college basketball with 12.0 turnovers per game, forced 9.5 turnovers per contest, which was 25th-worst in the country.

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