Duke vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Jan. 6

The Louisville Cardinals (11-3, 1-1 ACC) will host the Duke Blue Devils (13-1, 2-0 ACC) after winning eight home games in a row.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Louisville Game Info and Odds

• Game day: Tuesday, January 6, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Duke is a 1.5-point favorite against Louisville on Tuesday and the total is set at 161.5 points. Here's a few betting insights and trends if you plan to place a wager on the outing.

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Duke vs. Louisville: ATS Betting Stats and Trends

• Duke is 6-8-0 ATS this season.
• Louisville is 9-5-0 ATS this year.
• Duke covers the spread when it is a 1.5-point favorite or more 42.9% of the time. That's more often than Louisville covers as an underdog of 1.5 or more (never covered this season).
• The Blue Devils covered the spread in a lower percentage of their home games than road games last season. They covered 11 times in 17 games when playing at home, and they covered nine times in 11 games when playing on the road.
• This season, the Cardinals are 6-2-0 at home against the spread (.750 winning percentage). Away, they are 1-3-0 ATS (.250).

Duke vs. Louisville: Moneyline Betting Stats

• Duke has come away with seven wins in the eight contests it has been listed as the moneyline favorite in this season.
• The Blue Devils have a mark of 7-1 in contests where bookmakers favor them by -118 or better on the moneyline.
• Louisville has been the moneyline underdog just one other time so far this season, a game it lost.
• The Cardinals have played as a moneyline underdog of -102 or longer in only one game this season, which they lost.
• Duke has an implied victory probability of 54.1% according to the moneyline set for this matchup.

Duke vs. Louisville Head-to-Head Comparison

• Duke is outscoring opponents by 21.8 points per game with a +305 scoring differential overall. It puts up 87.3 points per game (32nd in college basketball) and allows 65.5 per outing (28th in college basketball).
• Cameron Boozer leads Duke, averaging 23.0 points per game (third in college basketball).
• Louisville is outscoring opponents by 21.3 points per game, with a +297 scoring differential overall. It puts up 90.4 points per game (17th in college basketball) and gives up 69.1 per contest (83rd in college basketball).
• Ryan Conwell's 19.6 points per game paces Louisville and ranks 37th in the country.
• The Blue Devils record 38.7 rebounds per game (17th in college basketball) while conceding 28.4 per contest to their opponents. They outrebound opponents by 10.3 boards per game.
• Boozer leads the Blue Devils with 9.8 rebounds per game (19th in college basketball action).
• The Cardinals win the rebound battle by 10.0 boards on average. They record 39.6 rebounds per game, 10th in college basketball, while their opponents grab 29.6.
• Sananda Fru paces the Cardinals with 6.9 rebounds per game (177th in college basketball).
• Duke scores 108.6 points per 100 possessions (27th in college basketball), while allowing 81.5 points per 100 possessions (15th in college basketball).
• The Cardinals rank 23rd in college basketball averaging 109.4 points per 100 possessions on offense, and defensively are 32nd, allowing 83.7 points per 100 possessions.

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