NCAAB
Duke vs Louisville College Basketball Prediction, Odds, Picks, Best Bets for Jan. 26

The Duke Blue Devils (18-1, 7-0 ACC) will host the Louisville Cardinals (14-5, 4-3 ACC) after winning three straight home games.
Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.
Duke vs. Louisville Game Info and Odds
- Game day: Monday, January 26, 2026
- Game time: 7 p.m. ET
- TV channel: ESPN
- Location: Durham, North Carolina
- Arena: Cameron Indoor Stadium
Take a look at some betting insights for Duke (-8.5) versus Louisville on Monday. The over/under is set at 157.5 points for this game.
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Duke vs. Louisville: ATS Betting Stats and Trends
- Duke has put together a 10-9-0 ATS record so far this year.
- Louisville is 11-8-0 ATS this year.
- At home, the Blue Devils sport a worse record against the spread (3-6-0) compared to their ATS record on the road (5-1-0).
- The Cardinals have been better against the spread at home (7-5-0) than on the road (2-3-0) this season.
- Duke is 4-3-0 against the spread in conference action this season.
- Louisville has beaten the spread three times in seven ACC games.
Duke vs. Louisville: Moneyline Betting Stats
- Duke has been victorious in 12, or 92.3%, of the 13 contests it has been chosen as moneyline favorites in this season.
- The Blue Devils have been a -450 moneyline favorite on 10 occasions this season and won every game.
- Louisville has been the moneyline underdog only two other times so far this season, and it lost both games.
- The Cardinals have not yet played as a moneyline underdog of +340 or longer.
- Bookmakers have implied with the moneyline set for this matchup that Duke has a 81.8% chance of pulling out a win.
Duke vs. Louisville Head-to-Head Comparison
- Duke was the 11th-best squad in the nation in points scored (83.2 per game) and seventh-best in points conceded (62.8) last year.
- Last year, Duke was 24th-best in the nation in rebounds (35.6 per game) and 12th-best in rebounds conceded (27.3).
- Last season Duke was 17th-best in the nation in assists with 16.9 per game.
- Duke was the ninth-best squad in the country in turnovers per game (8.9) and 265th in turnovers forced (10.4) last season.
- Louisville was 65th in the nation last year with 78.5 points per game. At the other end of the court, it ranked 89th with 69.5 points allowed per contest.
- Last season Louisville pulled down 34.6 boards per game (47th-ranked in college basketball) and ceded 30.2 rebounds per contest (114th-ranked).
- Last season Louisville ranked 148th in college basketball in assists, averaging 13.9 per game.
- Louisville averaged 10.9 turnovers per game (150th-ranked in college basketball). It forced 12.2 turnovers per contest (93rd-ranked).
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