The Louisville Cardinals (8-19, 3-13 ACC) will visit the Duke Blue Devils (21-6, 12-4 ACC) after losing six road games in a row.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Louisville Game Info and Odds

• Game Day: Wednesday, February 28, 2024
• Game Time: 7:00 PM ET
• TV Channel: ACC Network
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

To help you make an informed wager on Duke-Louisville contest (in which Duke is a 20.5-point favorite and the over/under is set at 151.5 points), keep reading for a few betting insights and trends for Wednesday's game.

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Duke vs. Louisville: ATS Betting Stats and Trends

• Duke has compiled a 15-12-0 ATS record so far this year.
• Louisville has put together a 13-14-0 ATS record so far this season.
• Duke covers the spread when it is a 20.5-point favorite or more 60% of the time. That's less often than Louisville covers as an underdog of 20.5 or more (100%).
• The Blue Devils own a better record against the spread in home games (9-6-0) than they do in road games (4-6-0).
• The Cardinals have been better against the spread away (5-5-0) than at home (6-9-0) this year.
• Duke's record against the spread in conference games is 8-8-0.
• Against the spread in ACC play, Louisville is 9-7-0 this year.

Duke vs. Louisville: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 22 games this year and has walked away with the win 18 times (81.8%) in those games.
• The Blue Devils have yet to lose in three games when named as moneyline favorite of -4500 or better.
• Louisville has a 2-16 record in games it was listed as the moneyline underdog (winning 11.1% of those games).
• The Cardinals have yet to play as a moneyline underdog of +1600 or longer.
• Duke has an implied victory probability of 97.8% according to the moneyline set for this matchup.

Duke vs. Louisville Head-to-Head Comparison

• Duke is outscoring opponents by 12.7 points per game with a +342 scoring differential overall. It puts up 80.4 points per game (35th in college basketball) and allows 67.7 per contest (69th in college basketball).
• Kyle Filipowski paces Duke, putting up 16.9 points per game (135th in college basketball).
• Louisville puts up 72.6 points per game (217th in college basketball) while allowing 78.6 per contest (334th in college basketball). It has a -164 scoring differential and has been outscored by six points per game.
• Skyy Clark's 13.3 points per game leads Louisville and ranks 489th in the nation.
• The Blue Devils are 136th in the nation at 36.2 rebounds per game. That's 4.7 more than the 31.5 their opponents average.
• Filipowski's 8.1 rebounds per game lead the Blue Devils and rank 83rd in college basketball play.
• The Cardinals are 182nd in the nation at 35.4 rebounds per game. That's similar to the 34.6 their opponents average.
• Brandon Huntley-Hatfield leads the team with 8.4 rebounds per game (67th in college basketball).
• Duke scores 106.2 points per 100 possessions (eighth in college basketball), while allowing 89.4 points per 100 possessions (90th in college basketball).
• The Cardinals average 92.2 points per 100 possessions on offense (244th in college basketball), and give up 99.9 points per 100 possessions (345th in college basketball).

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