Duke vs Lipscomb College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

Game day: Tuesday, December 16, 2025
Game time: 6 p.m. ET
TV channel: ACC Network
Location: Durham, North Carolina
Arena: Cameron Indoor Stadium

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The Duke Blue Devils (10-0) take a 10-game winning streak into a home matchup with the Lipscomb Bisons (6-4), winners of five straight.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Lipscomb Game Info and Odds

Here's a look at some betting insights for Duke (-31.5) versus Lipscomb on Tuesday. The over/under is set at 151.5 points for this game.

Duke has compiled a 6-4-0 ATS record so far this year.
Lipscomb has put together a 6-3-0 ATS record so far this year.
The Blue Devils did a better job covering the spread on the road (9-2-0) than they did in home games (11-6-0) last year.
The Bisons' winning percentage against the spread, both home and away, is .667. They are 2-1-0 ATS on their home court and 4-2-0 on the road.

Duke was the 11th-best team in the country in points scored (83.2 per game) and seventh-best in points conceded (62.8) last year.
Last season, Duke was 24th-best in college basketball in rebounds (35.6 per game) and 12th-best in rebounds allowed (27.3).
With 16.9 assists per game, Duke was 17th-best in college basketball last year.
Last season, Duke was ninth-best in the nation in turnovers committed (8.9 per game) and ranked 265th in turnovers forced (10.4).
On offense, Lipscomb posted 78.6 points per game (64th-ranked in college basketball) last year. It surrendered 67.7 points per contest at the other end of the court (52nd-ranked).
Lipscomb grabbed 32.9 rebounds per game (127th-ranked in college basketball). It ceded 31.4 rebounds per contest (195th-ranked).
Lipscomb delivered 15.1 assists per game, which ranked them 74th in the country.
Lipscomb was top-25 last season in turnovers, 25th-best in college basketball with 9.3 turnovers per game. Meanwhile, it ranked 250th with 10.5 forced turnovers per contest.

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