Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 10:11 p.m.

The Los Angeles Dodgers are among the MLB teams busy on Friday, versus the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (97-62) vs. San Francisco Giants (65-94)
• Date: Friday, September 25, 2026
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-335) | SF: (+270)
• Spread: LAD: -1.5 (-176) | SF: +1.5 (+146)
• Total: 7.5 -- Over: (+106) | Under: (-130)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Dodgers) - 11-7, 2.85 ERA vs Yunior Marté (Giants) - 0-1, 4.66 ERA

The Dodgers will call on Tarik Skubal (11-7) versus the Giants and Yunior Marte (0-1). When Skubal starts, his team is 8-17-0 against the spread this season. Skubal's team is 15-9 this season when he starts and they are the moneyline favorite. Marte has started two games with set spreads, and the Giants went 1-1-0. The Giants were named the moneyline underdog for two Marte starts this season -- they split the games.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (65.9%)

Dodgers vs Giants Moneyline

• San Francisco is the underdog, +270 on the moneyline, while Los Angeles is a -335 favorite despite being on the road.

Dodgers vs Giants Spread

• The Dodgers are 1.5-run road favorites on the runline against the Giants. The Dodgers are -176 to cover, and the Giants are +146.

Dodgers vs Giants Over/Under

• Dodgers versus Giants, on Sept. 25, has an over/under of 7.5, with the over being +106 and the under -130.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have been victorious in 94, or 62.3%, of the 151 contests they have been chosen as favorites in this season.
• Los Angeles has been a -335 moneyline favorite on three occasions this season and won every time.
• Contests with the Dodgers have gone over the total set by bookmakers in 73 of 157 chances this season.
• The Dodgers are 66-91-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Giants have gone 40-70 in games they were listed as the moneyline underdog (winning 36.4% of those games).
• San Francisco has played as a moneyline underdog of +270 or longer in just one game this season, which it lost.
• In the 156 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 76 times (76-70-10).
• The Giants have gone 75-81-0 ATS this season.

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 142 hits and an OBP of .381 this season. He has a .278 batting average and a slugging percentage of .521.
• Among qualifying hitters in the majors, he ranks 26th in batting average, ninth in on-base percentage, and eighth in slugging.
• Ohtani has recorded at least one hit in two games in a row. In his last five games he is batting .222 with a double, four walks and an RBI.
• Freddie Freeman has hit 16 homers this season while driving in 70 runs. He's batting .292 this season and slugging .435 with an on-base percentage of .366.
• He ranks ninth in batting average, 17th in on-base percentage and 57th in slugging in MLB.
• Kyle Tucker has 124 hits this season and has a slash line of .235/.332/.390.
• Mookie Betts has been key for Los Angeles with 122 hits, an OBP of .329 plus a slugging percentage of .455.

Giants Player Leaders

• Drew Gilbert has 14 doubles, three triples, 11 home runs and 37 walks while batting .240. He's slugging .398 with an on-base percentage of .329.
• Gilbert hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .556 with a home run and three RBIs.
• Marcelo Mayer has 10 doubles, three home runs and 18 walks while batting .213. He's slugging .303 with an on-base percentage of .281.
• Christian Koss has six doubles, four home runs and nine walks while hitting .228.
• Jonah Cox is hitting .266 with three doubles, two triples, four home runs and 10 walks.

Dodgers vs Giants Head to Head

• 9/20/2026: 3-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/19/2026: 10-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -450, Underdog Moneyline: +350)
• 9/18/2026: 8-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 5/14/2026: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/13/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/12/2026: 6-2 SF (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/11/2026: 9-3 SF (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/23/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/22/2026: 3-0 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/21/2026: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -186, Underdog Moneyline: +144)

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