Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 5:11 a.m.

The MLB's Friday schedule includes the Los Angeles Dodgers facing the San Francisco Giants.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (97-62) vs. San Francisco Giants (65-94)
• Date: Friday, September 25, 2026
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet LA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-375) | SF: (+300)
• Spread: LAD: -1.5 (-200) | SF: +1.5 (+164)
• Total: 7.5 -- Over: (+108) | Under: (-132)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Tarik Skubal (Dodgers) - 11-7, 2.85 ERA vs Yunior Marté (Giants) - 0-1, 4.66 ERA

The Dodgers will give the nod to Tarik Skubal (11-7, 2.85 ERA), who is eyeing win No. 12 on the season, and the Giants will turn to Yunior Marte (0-1, 4.66 ERA). Skubal's team is 8-17-0 against the spread in his starts this season. Skubal's team has been victorious in 62.5% of the games he's started as the moneyline favorite with a record of 15-9. Marte has started two games with set spreads, and the Giants went 1-1-0. The Giants were the underdog on the moneyline for two Marte starts this season -- they split the games.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (66.3%)

Dodgers vs Giants Moneyline

• San Francisco is the underdog, +300 on the moneyline, while Los Angeles is a -375 favorite despite being on the road.

Dodgers vs Giants Spread

• The Dodgers are favored by 1.5 runs on the road versus the Giants. The Dodgers are -200 to cover the spread, while the Giants are +164.

Dodgers vs Giants Over/Under

• Dodgers versus Giants on Sept. 25 has an over/under of 7.5 runs, with the odds on the over +108 and the under set at -132.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have come away with 94 wins in the 151 contests they have been listed as the favorites in this season.
• Los Angeles has been listed as a favorite of -375 or more on two occasions this season and won both games.
• The Dodgers and their opponents have hit the over in 73 of their 157 games with a total set by oddsmakers this season.
• The Dodgers are 66-91-0 against the spread in their 157 games that had a posted line this season.
• The Giants have been the underdog on the moneyline 110 total times this season. They've gone 40-70 in those games.
• San Francisco has played as a moneyline underdog of +300 or longer in just one game this season, which it lost.
• In the 156 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 76 times (76-70-10).
• The Giants have a 75-81-0 record against the spread this season.

Dodgers Player Leaders

• Shohei Ohtani has 142 hits and an OBP of .381, both of which are tops among Los Angeles hitters this season. He has a .278 batting average and a slugging percentage of .521.
• Among qualified hitters, he ranks 27th in batting average, his on-base percentage ranks eighth, and he is eighth in slugging.
• Ohtani hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .222 with a double, four walks and an RBI.
• Freddie Freeman has an OPS of .801, fueled by an OBP of .366 and a team-best slugging percentage of .435 this season. He's batting .292.
• His batting average ranks ninth among qualified players, his on-base percentage 16th, and his slugging percentage 57th.
• Kyle Tucker has 124 hits this season and has a slash line of .235/.332/.390.
• Mookie Betts has been key for Los Angeles with 122 hits, an OBP of .329 plus a slugging percentage of .455.

Giants Player Leaders

• Drew Gilbert is hitting .240 with 14 doubles, three triples, 11 home runs and 37 walks. He's slugging .398 with an on-base percentage of .329.
• Gilbert hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .556 with a home run and three RBIs.
• Marcelo Mayer has 10 doubles, three home runs and 18 walks while batting .213. He's slugging .303 with an on-base percentage of .281.
• Christian Koss is batting .228 with six doubles, four home runs and nine walks.
• Jonah Cox has three doubles, two triples, four home runs and 10 walks while hitting .266.

Dodgers vs Giants Head to Head

• 9/20/2026: 3-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/19/2026: 10-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -450, Underdog Moneyline: +350)
• 9/18/2026: 8-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 5/14/2026: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/13/2026: 4-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/12/2026: 6-2 SF (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/11/2026: 9-3 SF (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/23/2026: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/22/2026: 3-0 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/21/2026: 3-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -186, Underdog Moneyline: +144)

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