Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 1:11 p.m.

The Chicago Cubs are among the MLB squads in action on Sunday, versus the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Reds Game Info

• Chicago Cubs (86-69) vs. Cincinnati Reds (72-83)
• Date: Sunday, September 20, 2026
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-156) | CIN: (+132)
• Spread: CHC: -1.5 (-102) | CIN: +1.5 (-118)
• Total: 9.5 -- Over: (-115) | Under: (-105)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: David Peterson (Cubs) - 8-8, 5.11 ERA vs Rhett Lowder (Reds) - 6-11, 5.79 ERA

The Cubs will look to David Peterson (8-8) against the Reds and Rhett Lowder (6-11). Peterson's team is 9-11-0 against the spread in his starts this season. Peterson's team is 6-5 this season when he starts and they are the moneyline favorite. The Reds have an 11-12-0 record against the spread in Lowder's starts. The Reds have a 10-10 record in Lowder's 20 starts this season when they were the moneyline underdog.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (65.6%)

Cubs vs Reds Moneyline

• Chicago is a -156 favorite on the moneyline, while Cincinnati is a +132 underdog at home.

Cubs vs Reds Spread

• The Cubs are 1.5-run road favorites on the runline against the Reds. The Cubs are -102 to cover, and the Reds are -118.

Cubs vs Reds Over/Under

• A combined run total of 9.5 has been set for Cubs-Reds on Sept. 20, with the over at -115 and the under at -105.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have won in 58, or 56.9%, of the 102 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win 22 times in 33 chances when named as a favorite of at least -156 on the moneyline.
• The Cubs and their opponents have hit the over in 85 of their 150 games with a total set by oddsmakers this season.
• The Cubs are 72-78-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Reds have been the moneyline underdog 107 total times this season. They've finished 50-57 in those games.
• Cincinnati has a 12-21 record (winning only 36.4% of its games) when playing as a moneyline underdog of +132 or longer.
• The Reds have combined with opponents to go over the total 80 times this season for an 80-69-2 record against the over/under.
• The Reds have a 77-74-0 record against the spread this season (covering 51% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago with 167 hits and an OBP of .369, plus a team-best slugging percentage of .571. He's batting .277.
• He is 27th in batting average, 16th in on-base percentage, and second in slugging among all qualified batters in the majors.
• Alex Bregman is hitting .260 with 32 doubles, two triples, 26 home runs and 74 walks. He's slugging .451 with an on-base percentage of .350.
• Among all qualified, he ranks 64th in batting average, 42nd in on-base percentage and 45th in slugging percentage.
• Nico Hoerner is batting .265 with a .356 slugging percentage and 70 RBI this year.
• Hoerner takes a two-game hitting streak into this matchup. During his last five outings he is hitting .250 with a double and two RBIs.
• Seiya Suzuki is batting .267 with a .366 OBP and 84 RBI for Chicago this season.
• Suzuki takes a two-game hitting streak into this matchup. During his last five outings he is hitting .238 with a walk and three RBIs.

Reds Player Leaders

• Sal Stewart has a team-high .473 slugging percentage. He's batting .269 with an on-base percentage of .336.
• Including all the qualified hitters in MLB, his batting average is 43rd, his on-base percentage ranks 62nd, and he is 30th in slugging.
• Elly De La Cruz has collected 152 hits with a .367 on-base percentage to lead his team in both. He has a batting average of .286 while slugging .517.
• Including all qualifying hitters, his batting average places him 14th, his on-base percentage ranks 18th, and he is 10th in slugging.
• JJ Bleday has 16 doubles, two triples, 22 home runs and 70 walks while hitting .214.
• Tyler Stephenson has 21 doubles, 15 home runs and 48 walks while hitting .248.

Cubs vs Reds Head to Head

• 9/19/2026: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/18/2026: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

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