Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 4:11 a.m.

The MLB slate on Sunday includes the Chicago Cubs facing the Cincinnati Reds.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Reds Game Info

• Chicago Cubs (86-69) vs. Cincinnati Reds (72-83)
• Date: Sunday, September 20, 2026
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-154) | CIN: (+130)
• Spread: CHC: -1.5 (+105) | CIN: +1.5 (-126)
• Total: 10.5 -- Over: (+112) | Under: (-138)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: David Peterson (Cubs) - 8-8, 5.11 ERA vs Rhett Lowder (Reds) - 6-11, 5.79 ERA

The probable pitchers are David Peterson (8-8) for the Cubs and Rhett Lowder (6-11) for the Reds. Peterson's team is 9-11-0 against the spread this season in his starts. Peterson's team has been victorious in 54.5% of the games he's started as the moneyline favorite with a record of 6-5. When Lowder starts, the Reds are 11-12-0 against the spread. The Reds have been the moneyline underdog in 20 of Lowder's starts this season, and they went 10-10 in those games.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (65.4%)

Cubs vs Reds Moneyline

• The Cubs vs Reds moneyline has Chicago as a -154 favorite, while Cincinnati is a +130 underdog at home.

Cubs vs Reds Spread

• The Cubs are 1.5-run road favorites on the runline against the Reds. The Cubs are +105 to cover, and the Reds are -126.

Cubs vs Reds Over/Under

• A total of 10.5 runs has been set for the Cubs-Reds game on Sept. 20, with the over available at +112 and the under at -138.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have been favorites in 102 games this season and have come away with the win 58 times (56.9%) in those contests.
• This year Chicago has won 27 of 40 games when listed as at least -154 on the moneyline.
• The Cubs' games have gone over the total in 85 of their 150 opportunities.
• The Cubs are 72-78-0 against the spread in their 150 games with a line set by sportsbooks this season.
• The Reds have put together a 50-57 record in games they were the underdog on the moneyline (winning 46.7% of those games).
• Cincinnati is 14-24 (winning only 36.8% of its games) when it has played as a moneyline underdog of +130 or longer.
• The Reds have played in 151 games with an over/under set, and have combined with opponents to go over the total 80 times (80-69-2).
• The Reds have covered 51% of their games this season, going 77-74-0 against the spread.

Cubs Player Leaders

• Pete Crow-Armstrong has 167 hits and an OBP of .369 to go with a slugging percentage of .571. All three of those stats rank first among Chicago hitters this season. He has a .277 batting average, as well.
• Among qualified batters in baseball, his batting average ranks 27th, his on-base percentage ranks 16th, and he is second in slugging.
• Alex Bregman has 32 doubles, two triples, 26 home runs and 74 walks. He's batting .260 and slugging .451 with an on-base percentage of .350.
• Among qualifying hitters, his batting average places him 64th, his on-base percentage 42nd, and his slugging percentage 45th.
• Nico Hoerner has 160 hits this season and has a slash line of .265/.316/.356.
• Hoerner brings a two-game hitting streak into this game. In his last five games he is hitting .250 with a double and two RBIs.
• Seiya Suzuki is batting .267 with a .366 OBP and 84 RBI for Chicago this season.
• Suzuki brings a two-game hitting streak into this game. In his last five games he is batting .238 with a walk and three RBIs.

Reds Player Leaders

• Sal Stewart has racked up a team-high .473 slugging percentage. He's batting .269 with an on-base percentage of .336.
• Including all qualified hitters, he is 43rd in batting average, while his on-base percentage ranks 62nd and he is 30th in slugging.
• Elly De La Cruz leads his team with 152 hits and a .367 on-base percentage. He has a batting average of .286 while slugging .517.
• Including all qualified players, he ranks 14th in batting average, 18th in on-base percentage and 10th in slugging percentage.
• JJ Bleday has 16 doubles, two triples, 22 home runs and 70 walks while hitting .214.
• Eugenio Suarez is hitting .209 with 17 doubles, 24 home runs and 52 walks.

Cubs vs Reds Head to Head

• 9/19/2026: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/18/2026: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

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