Cubs vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 2:11 p.m.

The MLB schedule on Sunday includes the Chicago Cubs taking on the Boston Red Sox.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Red Sox Game Info

• Chicago Cubs (88-73) vs. Boston Red Sox (87-74)
• Date: Sunday, September 27, 2026
• Time: 3:05 p.m. ET
• Venue: Tropicana Field -- St. Petersburg, Florida
• Coverage: NESN and MARQ

Cubs vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | BOS: (+100)
• Spread: CHC: -1.5 (+146) | BOS: +1.5 (-176)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Cubs vs Red Sox Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 11-10, 3.74 ERA vs Tanner Houck (Red Sox) - 0-0, 0.00 ERA

The probable pitchers are Shota Imanaga (11-10) for the Cubs and Tanner Houck for the Red Sox. Imanaga and his team are 14-16-0 ATS this season when he starts. Imanaga's team has won 55.6% of his starts when they are favored on the moneyline (15-12). Last season Houck and his team had a 2-7-0 record against the spread when he pitched. Houck's team went 1-1 in games he appeared in when they were moneyline underdogs a season ago.

Cubs vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (56.3%)

Cubs vs Red Sox Moneyline

• Looking at the moneyline for Cubs-Red Sox, Chicago is the favorite at -118, and Boston is +100 playing at home.

Cubs vs Red Sox Spread

• The Cubs are at the Red Sox and are favored by 1.5 runs on the spread. The Cubs are +146 to cover the runline, with the Red Sox being -176.

Cubs vs Red Sox Over/Under

• An over/under of 7.5 has been set for Cubs-Red Sox on Sept. 27, with the over being -115 and the under -105.

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Cubs vs Red Sox Betting Trends

• The Cubs have been favorites in 108 games this season and have come away with the win 60 times (55.6%) in those contests.
• This year Chicago has won 54 of 98 games when listed as at least -118 on the moneyline.
• Contests with the Cubs have gone over the total set by bookmakers in 88 of 156 chances this season.
• In 156 games with a line this season, the Cubs have a mark of 73-83-0 against the spread.
• The Red Sox have been the underdog on the moneyline 46 total times this season. They've gone 23-23 in those games.
• Boston is 16-22 (winning 42.1% of its games) when playing as a moneyline underdog of +100 or longer.
• The Red Sox have played in 158 games with a set over/under, and have combined with their opponents to go over the total 69 times (69-87-2).
• The Red Sox have put together a 75-83-0 record against the spread this season.

Cubs Player Leaders

• Pete Crow-Armstrong has 174 hits and an OBP of .372 to go with a slugging percentage of .570. All three of those stats rank first among Chicago hitters this season. He has a .278 batting average, as well.
• Among all qualifying hitters in the majors, his batting average ranks 28th, his on-base percentage ranks 13th, and he is second in slugging.
• Alex Bregman has 32 doubles, two triples, 26 home runs and 75 walks. He's batting .260 and slugging .449 with an on-base percentage of .350.
• Among qualified hitters, his batting average places him 64th, his on-base percentage 42nd, and his slugging percentage 47th.
• Seiya Suzuki has 147 hits this season and has a slash line of .270/.368/.473.
• Nico Hoerner has been key for Chicago with 165 hits, an OBP of .317 plus a slugging percentage of .351.

Red Sox Player Leaders

• Wilyer Abreu is batting .249 with 38 doubles, four triples, 24 home runs and 70 walks. He's slugging .448 with an on-base percentage of .328.
• He ranks 80th in batting average, 76th in on-base percentage and 49th in slugging percentage among all qualified batters in the majors.
• Caleb Durbin is hitting .248 with 25 doubles, a triple, 13 home runs and 51 walks. He's slugging .379 with an on-base percentage of .333.
• Including all qualified hitters, his batting average places him 84th, his on-base percentage is 62nd, and he is 110th in slugging.
• Willson Contreras has 123 hits with a .387 on-base percentage, leading the Red Sox in both categories.
• Ceddanne Rafaela leads his team with a .442 slugging percentage.

Cubs vs Red Sox Head to Head

• 9/25/2026: 2-0 BOS (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/25/2026: 4-3 BOS (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/20/2025: 6-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/19/2025: 6-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/18/2025: 4-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/28/2024: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/27/2024: 17-0 BOS (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2024: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/16/2023: 11-5 BOS (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/15/2023: 10-4 CHC (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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