Cubs vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 12:11 a.m.

The MLB slate on Friday includes the Chicago Cubs facing the Boston Red Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Red Sox Game Info

• Chicago Cubs (88-71) vs. Boston Red Sox (85-74)
• Date: Friday, September 25, 2026
• Time: 1:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and MARQ

Cubs vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | BOS: (-102)
• Spread: CHC: -1.5 (+162) | BOS: +1.5 (-196)
• Total: 6.5 -- Over: (-114) | Under: (-106)

Cubs vs Red Sox Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-8, 3.25 ERA vs Alec Gamboa (Red Sox) - 1-0, 1.16 ERA

The Cubs will give the ball to Clay Holmes (6-8, 3.25 ERA), who is eyeing win No. 7 on the season, and the Red Sox will turn to Alec Gamboa (1-0, 1.16 ERA). When Holmes starts, his team is 6-11-0 against the spread this season. Holmes' team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 6-6. Gamboa has started two games with set spreads, and the Red Sox went 1-1-0. The Red Sox were named the moneyline underdog for one Gamboa start this season -- they lost.

Cubs vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.3%)

Cubs vs Red Sox Moneyline

• Boston is the underdog, -102 on the moneyline, while Chicago is a -116 favorite despite being on the road.

Cubs vs Red Sox Spread

• The Cubs are at the Red Sox and are favored by 1.5 runs (+162 to cover) on the runline. Boston is -196 to cover.

Cubs vs Red Sox Over/Under

• A combined run total of 6.5 has been set for Cubs-Red Sox on Sept. 25, with the over at -114 and the under at -106.

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Cubs vs Red Sox Betting Trends

• The Cubs have come away with 60 wins in the 106 contests they have been listed as the favorites in this season.
• This year Chicago has won 55 of 99 games when listed as at least -116 on the moneyline.
• The Cubs' games have gone over the total in 87 of their 154 opportunities.
• In 154 games with a line this season, the Cubs have a mark of 73-81-0 against the spread.
• The Red Sox are 21-23 in games they were the underdog on the moneyline (winning 47.7% of those games).
• Boston is 16-22 (winning 42.1% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 156 games oddsmakers have set an over/under for the Red Sox, they have combined with opponents to go over the total 68 times (68-86-2).
• The Red Sox have gone 73-83-0 ATS this season.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.373), slugging percentage (.575) and total hits (173) this season. He has a .280 batting average.
• Among qualified hitters in baseball, he ranks 22nd in batting average, 13th in on-base percentage, and second in slugging.
• Alex Bregman has 32 doubles, two triples, 26 home runs and 75 walks. He's batting .262 and slugging .452 with an on-base percentage of .352.
• His batting average is 55th among qualified players, his on-base percentage 41st, and his slugging percentage 41st.
• Seiya Suzuki has collected 145 base hits, an OBP of .366 and a slugging percentage of .476 this season.
• Suzuki enters this matchup with six games in a row with at least one hit. During his last 10 games he is batting .262 with a double, two home runs, three walks and five RBIs.
• Nico Hoerner is batting .264 with a .318 OBP and 72 RBI for Chicago this season.
• Hoerner heads into this game on a two-game hitting streak. During his last five outings he is batting .278 with a double, two walks and three RBIs.

Red Sox Player Leaders

• Wilyer Abreu has 37 doubles, four triples, 24 home runs and 70 walks while hitting .251. He's slugging .451 with an on-base percentage of .330.
• Including all qualified hitters, he ranks 79th in batting average, while his on-base percentage ranks 70th and he is 44th in slugging.
• Caleb Durbin is batting .250 with 25 doubles, a triple, 13 home runs and 51 walks. He's slugging .382 with an on-base percentage of .335.
• Including all qualified hitters, his batting average places him 81st, his on-base percentage is 59th, and he is 105th in slugging.
• Willson Contreras has a team-high OBP (.387), and leads the Red Sox in hits (123).
• Ceddanne Rafaela is slugging .442 to lead his team.

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