Cubs vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 12:11 p.m.

MLB action on Friday includes the Chicago Cubs taking on the Boston Red Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Red Sox Game Info

• Chicago Cubs (88-71) vs. Boston Red Sox (85-74)
• Date: Friday, September 25, 2026
• Time: 1:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and MARQ

Cubs vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-126) | BOS: (+108)
• Spread: CHC: -1.5 (+136) | BOS: +1.5 (-164)
• Total: 6.5 -- Over: (-112) | Under: (-108)

Cubs vs Red Sox Probable Starting Pitchers

Probable Pitchers: Clay Holmes (Cubs) - 6-8, 3.25 ERA vs Alec Gamboa (Red Sox) - 1-0, 1.16 ERA

The probable starters are Clay Holmes (6-8) for the Cubs and Alec Gamboa (1-0) for the Red Sox. Holmes and his team have a record of 6-11-0 against the spread when he starts. Holmes' team is 6-6 this season when he starts and they are the moneyline favorite. Gamboa has started two games with set spreads, and the Red Sox went 1-1-0. The Red Sox were named the moneyline underdog for one Gamboa start this season -- they lost.

Cubs vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (62%)

Cubs vs Red Sox Moneyline

• The Cubs vs Red Sox moneyline has Chicago as a -126 favorite, while Boston is a +108 underdog at home.

Cubs vs Red Sox Spread

• The Cubs are at the Red Sox and are favored by 1.5 runs on the spread. The Cubs are +136 to cover the runline, with the Red Sox being -164.

Cubs vs Red Sox Over/Under

• The Cubs-Red Sox contest on Sept. 25 has been given an over/under of 6.5 runs. The over is set at -112 and the under at -108.

Bet on Chicago Cubs vs. Boston Red Sox on FanDuel today!

Cubs vs Red Sox Betting Trends

• The Cubs have come away with 60 wins in the 106 contests they have been listed as the favorites in this season.
• This season Chicago has been victorious 47 times in 85 chances when named as a favorite of at least -126 on the moneyline.
• The Cubs and their opponents have gone over the total this season in 87 of their 154 opportunities.
• The Cubs have an against the spread record of 73-81-0 in 154 games with a line this season.
• The Red Sox have been the underdog on the moneyline 44 total times this season. They've gone 21-23 in those games.
• In games it has played as a moneyline underdog with odds of +108 or longer, Boston has an 11-16 record (winning 40.7% of its games).
• The Red Sox have had an over/under set by bookmakers 156 times, and have combined with opponents to go over the total in 68 of those games (68-86-2).
• The Red Sox have covered 46.8% of their games this season, going 73-83-0 ATS.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.373), slugging percentage (.575) and total hits (173) this season. He has a .280 batting average.
• Among the qualifying hitters in baseball, his batting average ranks 22nd, his on-base percentage ranks 13th, and he is second in slugging.
• Alex Bregman has 32 doubles, two triples, 26 home runs and 75 walks. He's batting .262 and slugging .452 with an on-base percentage of .352.
• Among qualifying batters, he is 55th in batting average, 41st in on-base percentage and 42nd in slugging percentage.
• Seiya Suzuki is batting .270 with a .476 slugging percentage and 86 RBI this year.
• Suzuki takes a six-game hitting streak into this game. During his last 10 games he is batting .262 with a double, two home runs, three walks and five RBIs.
• Nico Hoerner is batting .264 with a .318 OBP and 72 RBI for Chicago this season.
• Hoerner heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .278 with a double, two walks and three RBIs.

Red Sox Player Leaders

• Wilyer Abreu has 37 doubles, four triples, 24 home runs and 70 walks while hitting .251. He's slugging .451 with an on-base percentage of .330.
• Including all the qualifying hitters in the majors, his batting average is 77th, his on-base percentage is 69th, and he is 45th in slugging.
• Caleb Durbin is hitting .250 with 25 doubles, a triple, 13 home runs and 51 walks. He's slugging .382 with an on-base percentage of .335.
• He ranks 80th in batting average, 59th in on-base percentage and 105th in slugging percentage in the majors.
• Willson Contreras has totaled 123 hits with a .387 on-base percentage, leading the Red Sox in both statistics.
• Ceddanne Rafaela leads his team with a .442 slugging percentage.

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