Cubs vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 9:11 p.m.

The Chicago Cubs will face the Los Angeles Angels in MLB action on Friday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Angels Game Info

• Chicago Cubs (73-55) vs. Los Angeles Angels (61-66)
• Date: Friday, August 22, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and MARQ

Cubs vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-134) | LAA: (+114)
• Spread: CHC: -1.5 (+122) | LAA: +1.5 (-146)
• Total: 9.5 -- Over: (-112) | Under: (-108)

Cubs vs Angels Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 0-1, 5.63 ERA vs Tyler Anderson (Angels) - 2-8, 4.77 ERA

The probable starters are Javier Assad (0-1) for the Cubs and Tyler Anderson (2-8) for the Angels. Assad has a record of 0-2-0 ATS in two starts with a spread this season. Assad's team won his only start as a favorite this season. The Angels are 16-8-0 against the spread when Anderson starts. The Angels have been the underdog on the moneyline in 21 of Anderson's starts this season, and they went 10-11 in those matchups.

Cubs vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.6%)

Cubs vs Angels Moneyline

• The Cubs vs Angels moneyline has Chicago as a -134 favorite, while Los Angeles is a +114 underdog at home.

Cubs vs Angels Spread

• The Angels are hosting the Cubs, and are +1.5 on the runline. The Angels are +122 to cover the spread, and the Cubs are -146.

Cubs vs Angels Over/Under

• The Cubs-Angels game on Aug. 22 has been given an over/under of 9.5 runs. The over is set at -112 and the under at -108.

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Cubs vs Angels Betting Trends

• The Cubs have come away with 54 wins in the 84 contests they have been listed as the favorites in this season.
• Chicago has a record of 42-21 when favored by -134 or more this year.
• The Cubs' games have gone over the total in 58 of their 124 opportunities.
• The Cubs are 59-65-0 against the spread in their 124 games that had a posted line this season.
• The Angels have gone 43-49 in games they were listed as the moneyline underdog (winning 46.7% of those games).
• Los Angeles has a record of 31-35 when playing as a moneyline underdog with odds of +114 or longer (47%).
• The Angels have combined with opponents to go over the total 68 times this season for a 68-52-5 record against the over/under.
• The Angels have put together a 68-57-0 record against the spread this season (covering 54.4% of the time).

Cubs Player Leaders

• Kyle Tucker has 116 hits this season and a team-best OBP of .372. He has a .258 batting average and a slugging percentage of .443.
• Among all qualifying hitters, he ranks 81st in batting average, his on-base percentage ranks 15th, and he is 70th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (123) this season while batting .256 with 64 extra-base hits. He's slugging .510 with an on-base percentage of .297.
• Among qualified hitters, he is 85th in batting average, 139th in on-base percentage and 15th in slugging percentage.
• Seiya Suzuki is batting .245 with a .485 slugging percentage and 86 RBI this year.
• Nico Hoerner has an OPS of .709, fueled by an OBP of .338 and a team-best slugging percentage of .371 this season.

Angels Player Leaders

• Taylor Ward has racked up 111 hits, a team-best for the Angels. He's batting .235 and slugging .487 with an on-base percentage of .319.
• He ranks 133rd in batting average, 98th in on-base percentage and 28th in slugging percentage among all qualifying hitters in the majors.
• Nolan Schanuel leads his team with a .387 slugging percentage. He has a batting average of .269 with an on-base percentage of .357.
• He ranks 48th in batting average, 31st in on-base percentage and 127th in slugging percentage in the big leagues.
• Zach Neto is batting .267 with 26 doubles, a triple, 21 home runs and 27 walks.
• Jo Adell is hitting .232 with 15 doubles, a triple, 28 home runs and 28 walks.

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