Cubs vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 7:14 a.m.

The Chicago Cubs are among the MLB squads playing on Friday, up against the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cubs vs Angels Game Info

• Chicago Cubs (73-55) vs. Los Angeles Angels (61-66)
• Date: Friday, August 22, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and MARQ

Cubs vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-144) | LAA: (+122)
• Spread: CHC: -1.5 (+114) | LAA: +1.5 (-137)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Cubs vs Angels Probable Starting Pitchers

Probable Pitchers: TBA (Cubs) vs Tyler Anderson (Angels) - 2-8, 0.00 ERA

Anderson (2-8) will take the ball for the Angels. As of this writing, there's been no pitching decision announced by the Cubs. The Angels are 16-8-0 ATS in Anderson's 24 starts with a set spread. The Angels are 10-11 in Anderson's 21 starts this season that they were the underdog on the moneyline.

Cubs vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.1%)

Cubs vs Angels Moneyline

• Chicago is a -144 favorite on the moneyline, while Los Angeles is a +122 underdog at home.

Cubs vs Angels Spread

• The Cubs are at the Angels and are favored by 1.5 runs (+114 to cover) on the runline. Los Angeles is -137 to cover.

Cubs vs Angels Over/Under

• The over/under for the Cubs versus Angels game on Aug. 22 has been set at 9.5, with -105 odds on the over and -115 odds on the under.

Bet on Chicago Cubs vs. Los Angeles Angels on FanDuel today!

Cubs vs Angels Betting Trends

• The Cubs have been favorites in 84 games this season and have come away with the win 54 times (64.3%) in those contests.
• This season Chicago has been victorious 34 times in 50 chances when named as a favorite of at least -144 on the moneyline.
• The Cubs and their opponents have gone over in 58 of their 124 games with a total set by sportsbooks this season.
• The Cubs have an against the spread record of 59-65-0 in 124 games with a line this season.
• The Angels have won 43 of the 92 games they were listed as the moneyline underdog this season (46.7%).
• When playing as a moneyline underdog with odds of +122 or longer, Los Angeles has a 26-27 record (winning 49.1% of its games).
• The Angels have combined with opponents to hit the over on the total 68 times this season for a 68-52-5 record against the over/under.
• The Angels are 68-57-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker has 116 hits this season and a team-best OBP of .372. He has a .258 batting average and a slugging percentage of .443.
• Among all qualified hitters, he ranks 81st in batting average, his on-base percentage ranks 15th, and he is 70th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (123) this season while batting .256 with 64 extra-base hits. He's slugging .510 with an on-base percentage of .297.
• He is 85th in batting average, 139th in on-base percentage and 15th in slugging in the major leagues.
• Seiya Suzuki has collected 116 base hits, an OBP of .318 and a slugging percentage of .485 this season.
• Nico Hoerner leads Chicago with a slugging percentage of .371, fueled by 27 extra-base hits.

Angels Player Leaders

• Taylor Ward is leading the Angels with 111 hits. He's batting .235 and slugging .487 with an on-base percentage of .319.
• Including all the qualifying hitters in the majors, his batting average ranks 133rd, his on-base percentage is 98th, and he is 28th in slugging.
• Nolan Schanuel is slugging .387 to pace his team. He has a batting average of .269 with an on-base percentage of .357.
• Including all qualifying hitters, his batting average puts him 48th, his on-base percentage ranks 31st, and he is 127th in slugging.
• Zach Neto is hitting .267 with 26 doubles, a triple, 21 home runs and 27 walks.
• Jo Adell has 15 doubles, a triple, 28 home runs and 28 walks while batting .232.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!