Clemson vs LSU Prediction, Odds, Picks, Best Bets for Week 1 2025

College football's Saturday slate includes the Clemson Tigers facing the LSU Tigers.

We've got you covered, in terms of the most important info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Clemson vs LSU Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-182) | LSU: (+150)
• Spread: Clemson: -3.5 (-118) | LSU: +3.5 (-104)
• Total: 57.5 -- Over: (-105) | Under: (-115)

Clemson vs LSU Betting Trends

• Clemson was 6-8-0 against the spread last year.
• As 3.5-point or greater favorites, Clemson went 5-5 against the spread last year.
• In 14 Clemson games last season, six hit the over.
• LSU beat the spread five times in 13 games last year.
• LSU covered every time (2-0) as underdogs of 3.5 points or more last year.
• Out of 13 LSU games last season, five went over the total.

Clemson vs LSU Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (59.9%)

Clemson vs LSU Point Spread

LSU is listed as an underdog by 3.5 points (-104 odds), and Clemson, the favorite, is -118 to cover.

Clemson vs LSU Over/Under

Clemson versus LSU, on Aug. 30, has an over/under of 57.5, with the over being -105 and the under -115.

Clemson vs LSU Moneyline

Clemson is a -182 favorite on the moneyline, while LSU is a +150 underdog.

Clemson vs. LSU Points Insights

• The average implied total for the Clemson Tigers last season was 35.0 points, 4.0 more points than their implied total of 31 points in Saturday's game.
• The LSU Tigers' average implied point total last season (33.8 points) is 6.8 points higher than their implied total in this matchup (27 points).

Clemson vs. LSU Game Info

• Game day: Saturday, August 30, 2025
• Game time: 7:30 p.m. ET
• TV channel: ABC
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Clemson vs. LSU analysis on FanDuel Research.