Clemson vs Duke Prediction, Odds, Picks, Best Bets for Week 10 2025

College football's Saturday schedule includes the Clemson Tigers facing the Duke Blue Devils.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

Clemson vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-154) | Duke: (+130)
• Spread: Clemson: -3.5 (-104) | Duke: +3.5 (-118)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Clemson vs Duke Betting Trends

• Clemson has posted two wins against the spread this year.
• Clemson has won twice ATS (2-5) as a 3.5-point or bigger favorite this year.
• Out of seven Clemson games so far this year, three have hit the over.
• Duke has three wins in seven contests against the spread this year.
• There have been five Duke games (out of seven) that went over the total this year.

Clemson vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (51.7%)

Clemson vs Duke Point Spread

Duke is a 3.5-point underdog against Clemson. Duke is -118 to cover the spread, and Clemson is -104.

Clemson vs Duke Over/Under

The Clemson-Duke matchup on Nov. 1 has been given an over/under of 54.5 points. The over is -110 and the under is -110.

Clemson vs Duke Moneyline

Clemson is the favorite, -154 on the moneyline, while Duke is a +130 underdog.

Clemson vs. Duke Points Insights

Clemson vs. Duke Game Info

• Game day: Saturday, November 1, 2025
• Game time: 12 p.m. ET
• TV channel: ACC Network
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. Duke analysis on FanDuel Research.