Celtics vs. Pistons Prediction, Odds, Picks, Best Bets for Nov. 26

Celtics vs. Pistons Game Info

• Date: Wednesday, November 26, 2025
• Time: 5 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN, NBCS-BOS, and FDSDET

The Detroit Pistons (15-2) will try to build on a 13-game winning streak when they visit the Boston Celtics (9-8) on Wednesday, November 26, 2025 at TD Garden as just 2.5-point favorites. The contest airs at 5 p.m. ET on ESPN, NBCS-BOS, and FDSDET. The point total is set at 231.5 in the matchup.

Celtics vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Celtics vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Celtics win (68%)

Celtics vs. Pistons Betting Trends

• The Pistons have covered the spread 12 times over 17 games with a set spread.
• The Celtics have played 17 games, with seven wins against the spread.
• Games involving the Pistons have hit the over 10 times this season.
• Celtics games this year have gone over the total in seven of 17 opportunities (41.2%).
• Detroit has done a better job covering the spread at home (7-2-0) than it has in road affairs (5-3-0).
• The Pistons have hit the over on the over/under in six of nine home games (66.7%), compared to four of eight road games (50%).
• This season, Boston is 4-5-0 at home against the spread (.444 winning percentage). Away, it is 3-4-1 ATS (.375).
• In terms of the over/under, Celtics games have finished over five of nine times at home (55.6%), and two of eight on the road (25%).

Pistons Leaders

• Cade Cunningham is averaging 27.1 points, 6.0 boards and 9.6 assists. At the other end, he averages 1.3 steals and 0.7 blocked shots.
• Jalen Duren averages 20.3 points, 11.5 boards and 2.1 assists, shooting 67.1% from the floor (fourth in NBA).
• Ausar Thompson is averaging 12.6 points, 3.0 assists and 5.6 boards.
• Duncan Robinson is averaging 12.6 points, 2.9 rebounds and 1.9 assists. At the other end, he averages 0.9 steals and 0.3 blocked shots.
• Isaiah Stewart is averaging 10.6 points, 1.4 assists and 6.1 boards.

Celtics Leaders

• Jaylen Brown averages 27.9 points, 5.6 rebounds and 4.3 assists. He is also sinking 50.6% of his shots from the field and 34.4% from 3-point range, with 1.9 triples per game.
• Derrick White's numbers on the season are 15.4 points, 4.0 rebounds and 5.2 assists per game. He is making 35.3% of his shots from the field and 30.3% from beyond the arc, with an average of 2.5 triples.
• The Celtics are getting 16.6 points, 4.3 rebounds and 5.1 assists per game from Payton Pritchard.
• The Celtics receive 14.4 points per game from Anfernee Simons, plus 2.4 boards and 2.6 assists.
• Josh Minott averages 7.7 points, 5.1 boards and 1.3 assists. He is draining 51.1% of his shots from the field and 40.0% from beyond the arc, with 1.1 triples per contest.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.