Cavaliers vs. Pacers Prediction, Odds, Picks, Best Bets for Nov. 21

Cavaliers vs. Pacers Game Info

• Date: Friday, November 21, 2025
• Time: 7 p.m. ET
• Venue: Rocket Arena -- Cleveland, Ohio
• Coverage: Amazon Prime Video

The Indiana Pacers (2-13) are heavy underdogs (by 13.5 points) to break an eight-game road losing streak when they visit the Cleveland Cavaliers (10-6) on Friday, November 21, 2025 at 7 p.m. ET. The matchup has an over/under of 239.5 points.

Cavaliers vs. Pacers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Cavaliers vs. Pacers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (79.2%)

Cavaliers vs. Pacers Betting Trends

• The Cavaliers have put together a record of 6-10-0 against the spread this season.
• Against the spread, the Pacers are 6-9-0 this year.
• This season, Cavaliers games have hit the over eight times out of 15 chances.
• Pacers games this season have gone over the total in six of 15 opportunities (40%).
• Cleveland has done a better job covering the spread on the road (3-4-0) than it has in home games (3-6-0).
• The Cavaliers have hit the over on the over/under in a lower percentage of games at home (33.3%) than away games (71.4%).
• In 2025-26 against the spread, Indiana has a better winning percentage at home (.571, 4-3-0 record) than on the road (.250, 2-6-0).
• Pacers games have finished above the over/under 57.1% of the time at home (four of seven), and 25% of the time away (two of eight).

Cavaliers Leaders

• Donovan Mitchell averages 30.2 points, 4.5 boards and 5.3 assists, shooting 50.7% from the floor and 38.5% from downtown, with 3.9 made treys per contest (third in NBA).
• Evan Mobley's numbers on the season are 18.8 points, 8.6 boards and 4.0 assists per game, shooting 47.2% from the field and 34.8% from beyond the arc, with an average of 1.6 made 3-pointers.
• Jarrett Allen is averaging 14.8 points, 7.6 rebounds and 1.9 assists. Defensively, he averages 1.1 steals and 0.9 blocked shots.
• De'Andre Hunter is averaging 18.0 points, 2.8 assists and 4.7 boards.
• Craig Porter Jr. averages 6.1 points, 3.1 boards and 2.6 assists, shooting 54.2% from the floor.

Pacers Leaders

• Pascal Siakam averages 24.7 points, 6.9 boards and 4.9 assists. He is also sinking 45.9% of his shots from the floor and 35.1% from 3-point range, with 1.9 triples per game.
• The Pacers get 9.9 points per game from Jarace Walker, plus 5.1 boards and 2.8 assists.
• Isaiah Jackson's numbers on the season are 8.2 points, 6.2 rebounds and 1.1 assists per game. He is sinking 57.8% of his shots from the field.
• The Pacers are receiving 6.9 points, 4.5 rebounds and 1.8 assists per game from Ben Sheppard.
• The Pacers receive 6.4 points per game from Jay Huff, plus 3.0 boards and 0.9 assists.

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