Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 18

Odds updated as of 5:13 a.m.

The Wednesday schedule in MLB includes a matchup between the St. Louis Cardinals and the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (38-35) vs. Chicago White Sox (23-50)
• Date: Wednesday, June 18, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-196) | CHW: (+164)
• Spread: STL: -1.5 (-118) | CHW: +1.5 (-102)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 7-2, 3.84 ERA vs Sean Burke (White Sox) - 3-7, 4.71 ERA

This contest's pitching matchup is set, as the Cardinals will send Sonny Gray (7-2) to the mound, while Sean Burke (3-7) will take the ball for the White Sox. Gray and his team are 9-5-0 ATS this season when he starts. Gray's team has a record of 7-1 this season when he starts and they are the favorite on the moneyline. The White Sox have an 8-4-0 ATS record in Burke's 12 starts with a set spread. The White Sox are 6-6 in Burke's 12 starts this season that they were the moneyline underdog.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (61.5%)

Cardinals vs White Sox Moneyline

• Chicago is a +164 underdog on the moneyline, while St. Louis is a -196 favorite on the road.

Cardinals vs White Sox Spread

• The White Sox are +1.5 on the spread (-102 to cover), and St. Louis is -118 to cover the runline.

Cardinals vs White Sox Over/Under

• The Cardinals-White Sox contest on June 18 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have won in 15, or 48.4%, of the 31 contests they have been named as odds-on favorites in this year.
• St. Louis has not played a game this season with better moneyline odds than -196.
• The Cardinals and their opponents have gone over the total this season in 39 of their 73 opportunities.
• The Cardinals have posted a record of 40-33-0 against the spread this season.
• The White Sox have put together a 21-48 record in games they were the underdog on the moneyline (winning 30.4% of those games).
• Chicago is 6-26 (winning just 18.8% of its games) when playing as a moneyline underdog of +164 or longer.
• The White Sox have combined with opponents to go over the total 33 times this season for a 33-34-3 record against the over/under.
• The White Sox have a 39-31-0 record against the spread this season.

Cardinals Player Leaders

• Brendan Donovan has 83 hits and an OBP of .388 to go with a slugging percentage of .451. All three of those stats are tops among St. Louis hitters this season. He has a .323 batting average, as well.
• Among qualifying hitters in the majors, his batting average ranks fifth, his on-base percentage ranks 13th, and he is 55th in slugging.
• Donovan has hit safely in two games in a row. During his last five outings he is hitting .409 with two doubles and an RBI.
• Nolan Arenado is batting .244 with 11 doubles, a triple, eight home runs and 22 walks. He's slugging .388 with an on-base percentage of .306.
• Among all qualifying hitters, he is 102nd in batting average, 117th in on-base percentage and 115th in slugging percentage.
• Arenado brings a seven-game streak with at least one hit into this one. In his last 10 games he is hitting .286 with a double, a home run, two walks and five RBIs.
• Willson Contreras has 64 hits this season and has a slash line of .248/.337/.411.
• Lars Nootbaar has been key for St. Louis with 60 hits, an OBP of .330 plus a slugging percentage of .357.

White Sox Player Leaders

• Miguel Vargas has racked up a team-high OBP (.321) and slugging percentage (.441), while leading the White Sox in hits (62, while batting .242).
• Including all qualifying hitters in MLB, he is 107th in batting average, 94th in on-base percentage and 64th in slugging percentage.
• Vargas takes a six-game hitting streak into this game. During his last 10 outings he is hitting .270 with four doubles, a triple, two home runs, five walks and five RBIs.
• Chase Meidroth has five doubles, two home runs and 23 walks while hitting .276. He's slugging .337 with an on-base percentage of .358.
• Andrew Benintendi is batting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is batting .190 with eight doubles, six home runs and 26 walks.

Cardinals vs White Sox Head to Head

• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

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