Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 1:12 p.m.

The St. Louis Cardinals are among the MLB teams playing on Wednesday, up against the San Francisco Giants.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Giants Game Info

• St. Louis Cardinals (75-77) vs. San Francisco Giants (63-89)
• Date: Wednesday, September 16, 2026
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-162) | SF: (+136)
• Spread: STL: -1.5 (+132) | SF: +1.5 (-160)
• Total: 8.5 -- Over: (+106) | Under: (-130)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 5-14, 5.53 ERA vs Anthony Molina (Giants) - 3-1, 5.24 ERA

The Cardinals will give the ball to Matthew Liberatore (5-14, 5.53 ERA), who is eyeing win No. 6 on the season, and the Giants will counter with Anthony Molina (3-1, 5.24 ERA). Liberatore's team is 14-14-0 against the spread this season in his starts. When Liberatore starts a game and his team is the favorite on the moneyline, they have a record of 6-4. When Molina starts, the Giants are 2-1-0 against the spread. The Giants have a 2-1 record in Molina's three starts this season when they were the underdog on the moneyline.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.5%)

Cardinals vs Giants Moneyline

• San Francisco is a +136 underdog on the moneyline, while St. Louis is a -162 favorite at home.

Cardinals vs Giants Spread

• The Giants are +1.5 on the spread (-160 to cover), and St. Louis is +132 to cover the runline.

Cardinals vs Giants Over/Under

• The over/under for the Cardinals versus Giants game on Sept. 16 has been set at 8.5, with +106 odds on the over and -130 odds on the under.

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Cardinals vs Giants Betting Trends

• The Cardinals have been chosen as favorites in 50 games this year and have walked away with the win 27 times (54%) in those games.
• St. Louis has a record of 2-1 in contests when sportsbooks favor them by -162 or more on the moneyline.
• The Cardinals and their opponents have hit the over in 68 of their 148 games with a total set by oddsmakers this season.
• The Cardinals have an against the spread mark of 80-68-0 in 148 games with a line this season.
• The Giants have won 36.9% of the games this season they were the moneyline underdog (38-65).
• In games it has played as a moneyline underdog with odds of +136 or longer, San Francisco has a 14-16 record (winning 46.7% of its games).
• The Giants have combined with opponents to go over the total 73 times this season for a 73-66-10 record against the over/under.
• The Giants have a 72-77-0 record ATS this season (covering 48.3% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.472) thanks to 60 extra-base hits. He has a .285 batting average and an on-base percentage of .352.
• Among the qualifying hitters in baseball, his batting average ranks 17th, his on-base percentage ranks 41st, and he is 30th in slugging.
• Burleson has recorded at least one hit in three straight games. In his last five games he is hitting .353 with two doubles, a home run, two walks and seven RBIs.
• Jordan Walker leads St. Louis in total hits (160) this season while batting .280 with 61 extra-base hits. He's slugging .484 with an on-base percentage of .335.
• Among all qualifying players, he ranks 22nd in batting average, 62nd in on-base percentage and 23rd in slugging percentage.
• Ivan Herrera has 138 hits this season and a team-best OBP of .355.
• JJ Wetherholt has been key for St. Louis with 122 hits, an OBP of .343 plus a slugging percentage of .370.

Giants Player Leaders

• Jung Hoo Lee has accumulated a team-high .400 slugging percentage. He's batting .276 with an on-base percentage of .318.
• Including all the qualified hitters in the big leagues, his batting average ranks 32nd, his on-base percentage ranks 88th, and he is 91st in slugging.
• Bryce Eldridge is hitting .272 with 23 doubles, 17 home runs and 57 walks. He's slugging .465 with an on-base percentage of .363.
• Drew Gilbert is batting .231 with 14 doubles, three triples, nine home runs and 36 walks.
• Christian Koss is batting .240 with five doubles, four home runs and nine walks.

Cardinals vs Giants Head to Head

• 9/15/2026: 10-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +130)
• 9/14/2026: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/9/2026: 7-6 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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