Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 2:12 a.m.

The MLB's Tuesday slate includes the St. Louis Cardinals taking on the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cardinals vs Giants Game Info

• St. Louis Cardinals (75-76) vs. San Francisco Giants (62-89)
• Date: Tuesday, September 15, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-162) | SF: (+136)
• Spread: STL: -1.5 (+134) | SF: +1.5 (-162)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 12-6, 3.45 ERA vs Blade Tidwell (Giants) - 0-2, 4.82 ERA

The Cardinals will call on Andre Pallante (12-6) against the Giants and Blade Tidwell (0-2). Pallante's team is 14-11-0 against the spread in his starts this season. Pallante's team has been victorious in 41.7% of the games he's started as the moneyline favorite with a record of 5-7. The Giants have a 3-4-0 ATS record in Tidwell's seven starts with a set spread. The Giants have a 1-5 record in Tidwell's six starts this season when they were the moneyline underdog.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (60%)

Cardinals vs Giants Moneyline

• Looking at the moneyline for Giants-Cardinals, San Francisco is the underdog at +136, and St. Louis is -162 playing at home.

Cardinals vs Giants Spread

• The Cardinals are 1.5-run home favorites on the runline against the Giants. The Cardinals are +134 to cover, and the Giants are -162.

Cardinals vs Giants Over/Under

• An over/under of 8.5 has been set for Cardinals-Giants on Sept. 15, with the over being -105 and the under -115.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have won in 27, or 55.1%, of the 49 contests they have been named as odds-on favorites in this year.
• St. Louis has been listed as a favorite of -162 or more on two occasions this season and won both games.
• The Cardinals and their opponents have gone over in 67 of their 147 games with a total set by sportsbooks this season.
• The Cardinals are 80-67-0 against the spread in their 147 games with a line set by sportsbooks this season.
• The Giants have won 37 of the 102 games they were the underdog on the moneyline this season (36.3%).
• San Francisco has gone 14-16 when it has played as a moneyline underdog with odds of +136 or longer (46.7%).
• In the 148 games oddsmakers have set an over/under for the Giants, they have combined with opponents to go over the total 72 times (72-66-10).
• The Giants have a 71-77-0 record against the spread this season.

Cardinals Player Leaders

• Alec Burleson has an OPS of .819, fueled by an OBP of .352 and a team-best slugging percentage of .467 this season. He has a .285 batting average.
• Among all qualifying hitters in MLB, he is 17th in batting average, 40th in on-base percentage, and 33rd in slugging.
• Burleson hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .313 with two doubles, four walks and six RBIs.
• Jordan Walker has 160 hits, which leads St. Louis batters this season. He's batting .281 with 61 extra-base hits. He's also slugging .487 with an on-base percentage of .337.
• Among qualified hitters, he ranks 22nd in batting average, 59th in on-base percentage and 22nd in slugging percentage.
• Ivan Herrera leads St. Louis with an OBP of .356 this season while batting .243 with 73 walks and 93 runs scored.
• Nathan Church has 10 home runs, 50 RBI and a batting average of .252 this season.

Giants Player Leaders

• Jung Hoo Lee has put up a slugging percentage of .400, a team-best for the Giants. He's batting .277 with an on-base percentage of .319.
• Including all the qualifying players in the majors, his batting average puts him 31st, his on-base percentage ranks 88th, and he is 89th in slugging.
• Bryce Eldridge is hitting .269 with 22 doubles, 16 home runs and 56 walks. He's slugging .454 with an on-base percentage of .361.
• Drew Gilbert has 14 doubles, three triples, nine home runs and 36 walks while hitting .234.
• Christian Koss is hitting .229 with five doubles, four home runs and nine walks.

Cardinals vs Giants Head to Head

• 9/14/2026: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/9/2026: 7-6 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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